ID A0A194PRI5_PAPXU Unreviewed; 891 AA.
AC A0A194PRI5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Organic cation transporter 1 {ECO:0000313|EMBL:KPI93745.1};
GN ORFNames=RR46_12910 {ECO:0000313|EMBL:KPI93745.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI93745.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI93745.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI93745.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI93745.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000256|ARBA:ARBA00038485}.
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DR EMBL; KQ459601; KPI93745.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PRI5; -.
DR STRING; 66420.A0A194PRI5; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17317; MFS_SLC22; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950:SF25; ZINC TRANSPORTER SLC39A7; 1.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR Pfam; PF02535; Zip; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..541
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 99212 MW; 66348FA5452561EF CRC64;
MPKNNKGINY GSQENMPEKE DNDDPIDLDD LLPKIGEFGI YQKLLLWLVC LPACLPCGFC
AFNQLFMTDV PDHWCRVPEL QNFNLTEEQR KIMSIPRKAD DNTTFEKCSR YSVNWTEILS
TEEKFEINTS WPLEPCFDGY VYDKSEVKSS IVIDFDLVCD FDVYPTLGLV ALNVGGPIGV
YSFGILNDRI GRKKSFFTCL TTLLVGSLMT AYAHEYWFWV LARTVVGLTI PAVYQIPFII
SLELAGPNYR SFVTVMTCIF YTLGLILLSG VTYMLRDWRS LALATSVPFF LYYLYWFVLP
ESPRWLLMRK RFEEANKILK SIARVNGKEL PVEYTNKIQR QVLEQAMSGD KEAETASMFA
LCRTPNMRLK TCLITLNWCA SEMVYVGLSY YGPAIGSNQY MSFFLSSAVE IPSYLVCWVL
MDRVGRRWPL CLSMVISGIF CIVTVLLPND AETETLILYL ISKCFISASF LIIYPYAGEL
YPTELRGVGI GTSAYIGGLG LIIIPFVNYL GSSNLVLPLV VMGAVSVVGG LTALRLPETL
HTSLPQTAEE GEEFGKDWTY ADCFKCGGQR PVAEAESYEN LDQLELTQPP TEMDDEVSEM
PTIRRSSMRK LVRQASIVET QRDLDGNMKM TVEKQPLLKI LLSFASGGLL GDAFLHLIPH
ALTSHDDGHG HGHSHGHHEE GQHEPHDMTV GLGVLGGIIT FLVVEKTVRL FSGGHGHSHS
TDKKKDDNKS KKSNKPKKEE IKIAGYLNLA ADFTHNFTDG LAIGASFIAG QSIGYITTIT
ILLHEIPHEI GDFAILVQSG CSRRKAMMLQ LLTAFGAISG TVISIYLKGS SDGLVSSLIL
PFTAGGFIYI ATVSVIPELL EGSNNKFSQS VKEILALLAG VYMMVLIAQY E
//
