ID A0A194PSD4_PAPXU Unreviewed; 713 AA.
AC A0A194PSD4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Exostosin-2 {ECO:0000313|EMBL:KPI95878.1};
GN ORFNames=RR46_11591 {ECO:0000313|EMBL:KPI95878.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI95878.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI95878.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI95878.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI95878.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR EMBL; KQ459595; KPI95878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PSD4; -.
DR STRING; 66420.A0A194PSD4; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProt.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..376
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 451..696
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 713 AA; 82773 MW; 25F1CD96784E272B CRC64;
MATETLLKTN KHSKYISYRK ILYHRFFVGL LLFIVVSLVF TVLFNIYAGS SPRTEIYEPV
SLDLVSLQVT KIKINAPYSA PRYGNCTYWS CFNVYKCGRG GHDKITIYIY PLREYRTEEG
RLISQLSKEF YEILDTIRHS KYYTANPEEA CLLVPSIDTL NQNTFSSKHV SQALQSLQYW
NNGENHLIFN MLPGSSPNYE TVINLNTSKA IIAGSGFNTW TFRYGFDISI PLYSDVARGI
DNKQPEQKNY LIISTQQNIP DDYLAELQNI ASSSNDLLLL GNCKDSNRID HMKRCEYTTG
RIFNYPDILK EGMFCLVVRS ARLTQSVLLD ILASQCIPII IADTIILPFN SHVDWHRISL
YLPEDNIKNL LRIVHSVSKE RRGELYWQLR WVYEKYFASI EKITLTTLEI LNEKVFPLAA
RMYEEWNMPE HLYGPVNPLF LPVTAPKSPG FTAVILTYDR VDSLFTLIKK LVRTPSLAKI
LVIWNNQKKP PPPSSEWPVI NKPLKVIRTK ENKLSNRFYP YDEIETECQL TIDDDIIMLT
PDELEFGFDV WREFPDRIVG FPSRLHVWDN VTASWKYHSE WTNQISMVLT GAAFHHKIWS
WYYTYKMPAE IRTWVDDHFN CEDIAMNFLV ANVTRKPPIK VTPRKKFKCP ECTNTEMLSA
DARHMSQRSA CIHRFTKIYG HMALQAVEFR ADPLQYRETN SGVPQLYPDI GAL
//
