ID   A0A194PTJ6_PAPXU        Unreviewed;       390 AA.
AC   A0A194PTJ6;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Homeobox protein PKNOX2 {ECO:0000313|EMBL:KPI96298.1};
GN   ORFNames=RR46_12328 {ECO:0000313|EMBL:KPI96298.1};
OS   Papilio xuthus (Asian swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI96298.1, ECO:0000313|Proteomes:UP000053268};
RN   [1] {ECO:0000313|EMBL:KPI96298.1, ECO:0000313|Proteomes:UP000053268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI96298.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPI96298.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC       {ECO:0000256|ARBA:ARBA00009661}.
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DR   EMBL; KQ459593; KPI96298.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194PTJ6; -.
DR   STRING; 66420.A0A194PTJ6; -.
DR   Proteomes; UP000053268; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:UniProt.
DR   GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:UniProt.
DR   GO; GO:0001654; P:eye development; IEA:UniProt.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   PANTHER; PTHR11850:SF388; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000313|EMBL:KPI96298.1};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT   DOMAIN          253..316
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        255..317
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          135..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  42610 MW;  81C91750ED7CB281 CRC64;
     MQGGAPAADA DQAQFEADKR AVYKHPLFPL LALLLERCEQ ATAGAEAPAA DAFGADLQAF
     VQHQRRDRRP FLVDDPEIDG LMIKSIQVLR IHLLELEKVQ ELCRDFCGRY IACLKTKMQS
     ENLLRTDYTS GGIESNNNLS GTMDDHSSTS NSPQYQVPKS PPAPLAAATY PAVFPPHAAL
     PAHAPHAPAD MHYAQTHRDP ASMVVQGSTP ISQIGAGLVA ADTFTGTNSS TSNQSALSQS
     CSSLSGSPPP DDEEEGGKRG VLPRHATQAM RAWLFQHLVH PYPTEEEKRS LAAQTRLTLL
     QVNNWFINAR RRILQPMLDC NDKPGGKKSK NGSSISKRYW PDALTNPQYT AGLLSSSEDE
     EQDGEQSGEE QESQHEESSD SAYPIQQSMH
//