ID A0A194PTS0_PAPXU Unreviewed; 853 AA.
AC A0A194PTS0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Beta,beta-carotene 9',10'-oxygenase {ECO:0000313|EMBL:KPI96811.1};
GN ORFNames=RR46_04936 {ECO:0000313|EMBL:KPI96811.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI96811.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI96811.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI96811.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI96811.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
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DR EMBL; KQ459592; KPI96811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PTS0; -.
DR STRING; 66420.A0A194PTS0; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004294; Carotenoid_Oase.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR Pfam; PF03055; RPE65; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 37..185
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 191..348
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT BINDING 529
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 587
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 657
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 845
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 853 AA; 95732 MW; 82AFFC548BB7266F CRC64;
MIVPNAKFRN YVMSEVLAQI EKECERYCPA PRVPPRKVAI VGAGSDVGRV AALFLKQQPV
VRKLSLYDDE PDSCVMGVAN DLAHIDTSPD VEAFQGRPRL GDALTNSDVV LICGGHFVTP
PCCCALDREL FFKNMERVRV ASIACARFCP YAVVAVQTPP VDCNFALCMH TLKTAGVYDK
RRVLGVNSIS SMRANQLFCA LTGADPATTQ TPVICGTGRC TRVPVFSKGK AGNFPQTQVE
CLTKLVREAD EIICKVKANY EQGHLSIGFS SARFVTSVMQ GLFEKKTFID SALVEQDHAE
KCYGMKICAT PLSIGKGGIV EYVVPTLNEV ETKLLEESKC DLEDMLNLGR CYAVGDEYCL
NPCKIYTFPP CVPCEICRPS HIPPWLQGTL LRNGPGTLKV GSMSFDHVFD GSALLHSFKI
SEGTATYQCR FVRTDAYKRN KAANRIVVTE FATESVPDPC HTIFDRFTAF FKPLEKLSDN
TVVSVYPIGD EIYTFTESPI IHRIDPKTLK TLERKDLIKD FAIVNHSAHP HILPNGDVIN
IGLSYTSRGM RHVVIHFPFT EKGDMFERAH IVGGMKPRWQ MHPSYMHSFG ITENYFVLIE
QPMTISLRTV LWNVFLDKPF ASALQWYPKL ETNIVLIGRK TGEEVRRYRT ETLFYFHVIN
AFEDGQNVVL DFCTYKDAKI LNGMYIKAME SIQSNEDCAE WFRARAKRLK MPLESPDMTF
VEAKLLANIG CETPRIHYNM YNGRSYRYFY AISSDIDNIN PGAVVKVDTW TGDYETWFEA
GSFASEPVFV PEPQAQEEDA GILLCVLLYG SHICKISLLL LDSRTLLEIG RVTFDTPSPS
PKCIHGWFIS DRV
//
