ID A0A194PY48_PAPXU Unreviewed; 1682 AA.
AC A0A194PY48;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=phosphatidylinositol-3-phosphatase {ECO:0000256|ARBA:ARBA00013038};
DE EC=3.1.3.64 {ECO:0000256|ARBA:ARBA00013038};
DE AltName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
GN ORFNames=RR46_09482 {ECO:0000313|EMBL:KPI98266.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI98266.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI98266.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI98266.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI98266.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; KQ459585; KPI98266.1; -; Genomic_DNA.
DR STRING; 66420.A0A194PY48; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd15738; FYVE_MTMR_unchar; 1.
DR CDD; cd13210; PH-GRAM_MTMR6-like; 1.
DR CDD; cd14532; PTP-MTMR6-like; 1.
DR Gene3D; 1.10.238.20; Pheromone/general odorant binding protein domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR028089; DUF4455.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF14643; DUF4455; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF01395; PBP_GOBP; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF47565; Insect pheromone/odorant-binding proteins; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 908..1280
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT ACT_SITE 1118
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 1056..1057
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 1118..1124
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 1682 AA; 191389 MW; 1E338E42F720DE6F CRC64;
MLRKKLSFKN EKTYKCLCVQ RPKVKPYVAG CENDAAAVSV LPYHWTPRRS GSILSNYLKK
REEDHHKLIK ELQDCMGVIN EDIEEKIRVL AETLLCHINH SQHDIDCVIK KYSSIEGALP
IEARDEALKR IQKIITERMQ EVNDFKADAL QLEKERASRL KKALHDSFNS IVAIGHTSPK
NVLNEFDEKM YEINQQLLSN CSAYHELETQ LRAQANENQR KARAQINQLC LGVAITRREH
SALSCSSNNR IVHKRITSAH IKENTDKLQL SQPPINAKND NISILRLTEE YQKAVADLYY
DFIKNVNVLY HRIGDGNFIQ NKICCNNQVI DEKLEHINRN RFSLTNLNSK IGDDENISEI
SNCIKMIQNS LTSVGKELKD TYTLLHESCH LWDAHMIRVA LAQKLTLAAV EDLISKHDSL
ELASELPFNI TFEQLLTAND VDKLQSFYEV LLALLKQKSN EYTYHSEAEI GRLNELANLH
VPLSNTVQAE FDLFISKHPI ASYLITGSED SIQDTRARLS GCDMKVALSR EIFQTEVQEI
ALSNWRNGFL ESFQNSLPLL SEKLERQVKT WLSERSLPLK KRLALKLMSL EVRKERIAAA
RDVRLAELRS HEACLESHIG AINSLVTSLP QEVAQFITFD NPNLYQISQW LNSIKAGMEE
LDSPEVDAEV KRLKMLSYST RLSNHRREFD ESLTSIAELC KKFIANRVQQ ARIANVQYIS
HLKLFNEGGN YSALEAMKIT SALVKGGDAL ESCMTKSLDS LHHRCNEILT EVDRTVNSLQ
AIAEETLKET GKLENVQLLD KYNVRNPSKG TLYFATTHLI FVDHDMRKET WILLMHISSV
ERLPITTTGS PLLVRTKTFQ SVFFVIPRER DCHEMHQTLL RLSQPVHIEE LYCFHYKSTP
DDLPKSAGWN FFDIQTEYQR MNVPNEHWVL CNANRDYELC DTYPSEVYVP ARASTAVLLG
SASFRSRGRL PALAYLHHNK AAIARCSQPL SGFSARCMED EQMLDLIRRA NPNCGYMYVV
DTRPRINAMV NRAAGKGYEN EAFYENIKFQ FMGIGNIHVM RKSLQKLVET CEQNTPSMSS
FLSGLESSGW LKHIKSILET SWWIASAVSG GVSVCVHCSD GWDRTAQACS LAALCLDPHY
RTINGYQALI EKDWLSFGHK FAARCGHVAG DSRERAPVFT QLLDCTWQLF RQAPQAFQFN
ERFLLTLHDH AHACQYGTFI GNCQKDRRDL RLSERTFSLW GYMASHLSEY KNPLYNPKAH
PDLLKPDLSA QSIRFWRGMY CRHEGGVHPR EPLADLLPAA VQHASALDYH INYLAKRIST
FKNLLSGRRT EKSREKDAVV NYQNGDIDTV DIDTKTEALQ IDNKLLYESS GGLSELECAN
HDHPLKEAAP AHKPTNIPLI TERVEDSVPA SLAALESEVH SVALDWKSLK NVTECSCSTP
LDHYSRSVCQ HHCWGCGRCV CTRCVCRRAP LPGLAAPRQA PLCAACAPTT PAVLCNEQKS
KTQEKDDIGL DTVHTIKIDK NTVISRNLKL ERKDRRNAKT KQEEKELHWS YSGFPNEVSP
HVEQFRRNMT ECLKEVEAKE KKTVRRLSPK KDSPIHGECL IACVLKRNGV INKGKIVKAN
LILLVSKFFA RDTKLLKKLD KNVDKCIEAS SKNKDECAMA SQLNDCTNDL MASNKHKILL
NY
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