ID A0A194Q2Z2_PAPXU Unreviewed; 932 AA.
AC A0A194Q2Z2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE SubName: Full=Ras GTPase-activating protein 1 {ECO:0000313|EMBL:KPI99708.1};
GN ORFNames=RR46_02622 {ECO:0000313|EMBL:KPI99708.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI99708.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI99708.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI99708.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI99708.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ459564; KPI99708.1; -; Genomic_DNA.
DR RefSeq; XP_013169997.1; XM_013314543.1.
DR AlphaFoldDB; A0A194Q2Z2; -.
DR STRING; 66420.A0A194Q2Z2; -.
DR GeneID; 106119507; -.
DR KEGG; pxu:106119507; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 66..156
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 163..225
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 235..323
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 362..468
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 465..581
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 637..831
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 104760 MW; 7B2C76CA4B8D8DCF CRC64;
MADLIRAMGA PIGPPVKDKL GSPSTESEDG GADPAELAAD LELDEADGPS TNGERQAVLA
PPESEWYHGR LDRYTSEERL WAASKQGSYL VRESDRKPGS YVLSYLGRTG INHFRITAVC
GDYYIGGRQF DSLTELVGFY SHCSDLLKRE RLVEPVPPPE PVNDKKRVVA ILPYTKMPDT
DELTFQKGDI FFVHNDMGDG WLWVTAHRTG EQGMIFRELV EDLDPSIDPN TVFSWFHPNC
TKSEAVDMLV KAGPGSFLVR PSDNSPGDYS LFFHINNQIQ RFRIEKKGVR YLMGGRVFEC
LDAVINRYRK EQIVEGHTLG QPLIAEGHHI EPQQNTTGAA AEKIYATLRE CRDQIGLKKM
KGIKHQGYLN KKSDKAAKKW KALYFVLLQE GTDTHLYFYD SPKRTKPKGL IDLSCAYLYQ
VHESLWEREF CFQLVERALP CLSTHTFLAA SSQADERAWL DALRPLCVPQ QARHQCKVAR
VVWLRALRVR CVTAHRLPPR LAPRPHLRLA LGAAPVARTR AKPSPDPHWD DEFVFDDVPP
DVTSFTITVH NTGKRGKESE VAELTIELAN LANGEEVEEW YPLAGMTPIG EWGSLRLRIR
YMQELVMPRE EYNPLRQLLL EPGIPAVKAL AELCRTDRQP LATSILQTFS ECGRGAELAR
ELAGAEVARE ADHRALFRAA SLATAVIDEF MHALCKPFLQ AAIAETVQKL IDSKQSAELN
PTKMDSPEDA CNNAEFLLLI LDQITHSIFL TPESCPRAVR YVCGCLQRAA VAKWPSERFV
RTRVVSGFIF LRLICPALVE PRAWGLVSST PPPHAQRSLL MVAKCLQNLA NLVEFGAKEP
YMEVVNPFIL KNKERMIAFL DQLSSVPDPG TAPPNTNNNF DIAKELATLH HICVSHLSEL
QTLGKSQPAI RKLVTVTEML TKHKHKYLEM IR
//
