ID A0A194Q4B9_PAPXU Unreviewed; 1985 AA.
AC A0A194Q4B9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Myotubularin-related protein 5 {ECO:0000313|EMBL:KPI98255.1};
GN ORFNames=RR46_09471 {ECO:0000313|EMBL:KPI98255.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI98255.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI98255.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI98255.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI98255.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ459585; KPI98255.1; -; Genomic_DNA.
DR STRING; 66420.A0A194Q4B9; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14534; PTP-MTMR5-like; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..432
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1142..1661
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1788..1838
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1881..1985
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 816..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1985 AA; 218449 MW; 8153EEBAA8A012AB CRC64;
MSRLVDYFVI VGFDHEKERG GHSNGVILQR FPETNWDDTP FHEGIEWFCQ PQGWSLSTER
SEPRFYVSVL TDVDANRHYC ACLCFNETVA ITPTKPADED EESLESSRPV ANITHHSIMY
APKCLVIVSR QDYIDTFRNC LGIIYTVWVE NLGVPLETLV GNLVGCVLVP GAGGPQVRFS
IGAGDRQALQ PPAAPPMPVT HTAVHMLLRL LGIHNSVTLW CAVMSEHKVL LVSLAAARLS
AACRALAALM FPFRYAHVYI PLLPAGLAEV LATPTPFLIG VHSSLKEEVS ELLDVIVADL
DVGSLHIPAG VNIPRPEGKL LGSLQEALAL VLQPELRSAD SAFAPPPPAA SPPHMLDKEI
RAVFMRTLAK LLQGYRHCLT IIRIHPSPVL TFHKAGFLGS RGLAACPFAV RLLDSMFFNG
LVAERGPPWR PTDIFDELVQ NLPEQLRLES LNPDIELQHI QDLAMQLHLN ENPNPQTYQQ
RVLRPPAGAE ARIHQPPLPA LDPLRVRDVI RDVSQRNTNN AKLTALRPPQ ARIVPPAAPP
TGGEEPGQLL LTNSARRLEV LRACVAAIFE GRYADARKSF PAVLRALRAP AARSALVRDL
AARLPTNKHL LQHHQFELLV RLMNCALQSA TALDEHSIAA AMLPLATAYC RKLCTGVIQY
AYMCIQEHQV WTSQQFWEAA FYQDVQRDIK ALYLPSPTHH QRVPSPREDE EYISLLKAQE
PSALEIAAEQ MRLWPTLPPD KCSIKMEDEE YISLLKAQEP SALEIAAEQM RLWPSLPPEK
QRELIASEES TLYSQAIHYA NRMVYLLLPL EGAGRRADAR GDDADRASNS ITNSVAESDS
ADAESGFEEA DPGEAGNNVI KMVSRFVDKV CTEGGVTADH VRCLHQMIPG VVHMHLETLD
AVARESRRLP PVQKARIVAP SMVPGEAGAA PALRAVLVAD GRESPLLPAE GALFLTNYRL
VFKGTPIDPF ACEQTVVRSF PLCALTREKA VRAHGPQLEP LSDGLQLRAA TFQLIKVVLD
EEVSGEQAEA FRKQVARLRH PASAVLHFAL APRPAPPPPL HAAKHHTLKG FAKKTLLKTA
RRAGLKPKPS KRQKYVLPSA DARSLTSPPL MSSLSADTLS LEELELGGTD SAEPPAARTL
ERVRERIYAR DWARLGLASA PFRLTHANAI YTLCRSYPCV VAVPAAVSDE SLRRAARCYR
QGRLPALTWR HPRTHALLAR SSASHHKGVM GMLKGSSHQT PGTAQSGTEP TSSLEQERYL
SALIACTPAG RGELEAASLS LESLLLPEDH HTPLLAKATG TLGVLGRNSG GKGGAAGGRH
FGRWGSLKDR RQPSHLELYV PKQRLSTADL DSVCGESSGG GGGARRAALY VLTDKGGAGG
VSGGGAEAPA VQAVPVEYPD ARATKHAFKK LLRAAAPSAP PQHDHPGFLR LVEESGWLWQ
LRQLFQLSGA VVDLLDLQGS SVLLSLEDGW DVTSQISSLA QICLEPYYRT LEGFRILVEK
EWLAMGHKFQ QRSNLAAAPQ QGFTPTFLMF LDAVHQLVKQ FPLAFEFNDY YLRFVAYHSV
SCRFRTFLFD SEAQRAELGL AHADDRRADV TRLGVETGAG AGEEECGGRA AAHGVSLFDF
VERVHQRTPL FYNFLYTPDF DNPVLRPVSA INCLEVWEYY VSEELSHGAP YDLDLVPNGD
AEPRAARRVV TAGYDSVSRC MPDAFSGLLE RVRQLELELG HLPQKWRVRW DQLELPNTLE
LQRNASMCSS VVRRATAAAH RRGTLEVLVR GLAAAPQHAP HAPHAAPAHR WAPAAHAAPA
RCDHCGDLLW GPLETGVRCV DCGAACHERC AETFALPCTK YKAPPPDRDR DLRTNVANSV
ATLQSSSQQY YEQFSSNVAE DRTHEGHLYK RGALLKGWKQ RWFVLDSIKH QLRYYDAMED
SHCKGFIDLA EVITVTQAAP APGPPKKCDD RSFFDLRTSR RTYNFCASDA NAAQEWIEKL
QACLQ
//
