ID A0A194Q991_PAPXU Unreviewed; 1368 AA.
AC A0A194Q991;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=DNA repair protein complementing XP-C cells-like {ECO:0000313|EMBL:KPJ01984.1};
GN ORFNames=RR46_05193 {ECO:0000313|EMBL:KPJ01984.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ01984.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ01984.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ01984.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ01984.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; KQ459299; KPJ01984.1; -; Genomic_DNA.
DR STRING; 66420.A0A194Q991; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 2.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 1111..1163
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 1165..1221
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 1228..1302
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1368 AA; 155981 MW; D039D2C41C1C6919 CRC64;
MPTTRKKVIK TVYKDDDESD NMGGDFSDSG SDAKISSAPS SDDSINEEEN CPSSDDEVHK
KPQKKTTNRK KNPQFAKAFI NKINKQISAE DEDEPLPVST FTIKDLTEAD KLLPSVLNLS
ESDSSDDECT KPIFKKKFHT ETLPNTDPEN DNNDAGTEYK DVWSVNEKDE SEEIAKKTFL
ELEQHKAKIE EAKMSVLKYS HNKNENESDV KDLLALGEEI VPEVGTITKK KKKKVQDQSD
SEVEDWEEVK EAKSIPQQGL QLIVDIPDSV ARRAKKVDVE MMMKRKMNRV KKECQVYMHK
VHVLCWLGYG NYISTVLNDQ EVMSTALSLL QKLKSKECSP GQKLPKIASC SKINLNFYPG
QRVDMKYVEQ ITSWYQNILT LRKDKHEGKF RPKAPKLKEI LIQQIRNRII TSKKYLVYVF
VSMLRAIGLH CRVMLNFVTV PIKPPAFELH SMSTKSTDKN KSDKKDVSKD KNITKSKSTK
TCSKKKISQL DGNYDYSTDS DSDISNIMQI DGNDDKMPRI TRSTRSNTKV NQNKQVATNS
DIISNKIMQV DGNNDEIHPK TQSRKAISKE NANIHKESEG ASPPKKAKQT DDNDTVQVAA
KSKLSLNRQR GKNVKSGNNL EVPEIEENKE VTASKFFVGD ENLNRRSTRK RSATTNARTS
NDTVVKEVTK KATQAKVRAK STPVRNVNSK SNEDLSESAS KKPKRSSKKQ ENNKDVLKPK
DMIDKNSDED DSIQNTKTQK SDSDDDFKIE KDIATISRNV KKPNSAKLKG KLSNQDITKD
DQNKQDEKEE SNSVVTAKTR SARATRNTKI VPKIEVSTEE NKEVTASDFF IGENTCTNVN
KTKLPRKRST TTNLKVNDTV KTETTEKNTK TRANNSPRSA NTSKYFKDDS TSKKAKNVRD
ENYIEDEQRV SHKDLLKQKT KAKNDVTSDL VDIIKTRVKE AKAETKKNKV KGTTKDSDED
SDQLPEEDIK PCVSDDDFKP VKLGPKPGTS RRIDRRVLSE DDEVLPDRID VWCEVFVEEL
EEWVPVDVIR NKVHCAKEIH SKATHPVAYI VGWDNNNYLK DLTRRYVPHW NTITRKQRAE
VSWWNTAVAP WLGPKNARDK EEDERLDRMQ LEAPLPTSIA EYKNHPLYAL KRHLLKFEAL
YPEDAATLGF VRGEPVYARE CVHICKSRDI WLKDAKVVRL GEKPYKVVKA RPKWDKLSNK
LITDKPLELF GPWQVTDYEP PVAENGIVPR NAYGNVELFK ECMIPKGTVH IKLPGLNRVA
KKLNIDCAPA LTGFDFNGGY SHPVYDGFVV CTEYEEILTE AWVKDQEELE RKEREKIDAR
VYGNWRRLIK GLFIRERLKH KYGFDGPIPG TSQDKKKQKG PRLVVKKR
//
