ID A0A194QH91_PAPXU Unreviewed; 1263 AA.
AC A0A194QH91;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN ORFNames=RR46_10014 {ECO:0000313|EMBL:KPJ02811.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ02811.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ02811.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ02811.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ02811.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459,
CC ECO:0000256|RuleBase:RU003732}.
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DR EMBL; KQ459232; KPJ02811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QH91; -.
DR STRING; 66420.A0A194QH91; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR CDD; cd10324; SLC6sbd; 2.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 2.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 2.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 2.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 2.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..979
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1056..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1134..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1176..1194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 17..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 139999 MW; FA4BFDB50F52A7E8 CRC64;
MVVLSANVKF QSQISEDHMN KGFDPSPETL PPITNGFDKK NMSAVPDKMN KPIEEGKEKV
DEEDDQPERA MWGNQLEFLM SCIATSVGLG NVWRFPFVAY QNGGGAFLIP YIIVLILIGK
PMYYLEGVLG QFSSRNSIKV WSMTPAMKGT GYAQALGCGY ILSYYVSIIA LCLYYLSMSF
QSTLPWAICA PEWLNCVPSE LTENVVLTEH STSSAELYFV KTVLQQSDGI EGGLGAPIWY
LTLCLLASWV IIFLIVARGV KSSGKASYFL ALFPYVVMII LLISTSILPG AGDGILFFVT
PQWDKLLELD VWYSAVTQVF FSLSVCTGAI IMFSSYNGFR QNVYRDAMIV TTLDTFTSLL
SGITIFGILG NLAYVLKQEV KDVVGTAGTG LAFISYPDAI AKTFQPQLFS VLFFLMMTVL
GVGSAVALLS TINTVLLDSF PRVPTIIMSA FSCSAGFLVG LVYVTPGGQY ILEMVDHYGG
TFLILFCAIA EVIGVFWFYG LENLCLDIEF MLGIKTSVYW RFCWGLITPA MMIVVFVYAL
ATSNELVFGT DYYYPVAGTV SGYLMLFVGV AFVPIGIIAV MYKNRTGNFY ETLKQSFRPK
STWGPRSTIT RNEWTLYKKD AMAEREKLQD SQNSNAKDDG GGQWNNAYDA APETADQSKS
DVESKKPQTK NKNATPERPK WDNQLEFLMS CIATSVGLGN VWRFPFVAYQ NGGGAFLIPY
IIILLIIGKS MYYLETVLGQ FSSSNCVKIW ALSPAMKGTG YVQALSAAYV LSYYVSIIAL
CFFYLAMSFQ SPLPWALCDA SWLNCVPSGE AVNMSSIQGN PVGSAELYFT QTVLRQSDGI
HDGIGVPLWD LTLCLLASWI IIFVIVARGV KSSGKASYFL ALFPYVVMII LLIRSVTLPG
AANGILFFVT PDWNKILEIR VWYAAVTQVF FSLSVCSGAL IMFSSYNGFR QNVYRDSMIV
TTLDTFTSLI SGITIFGVLG NLAYELNYDD VGQVIGAGGT SLAFISYPDA IAKSPVVPQL
FAVLFFLMMA VLGVGSGVAL LSTVNTVLLD AFPRIPTLYM SAMSCSVGFL VGLVYVTPGG
QYILELVDHY GGTFMRLFAA IIETIGVFWI YGLENLCTDI EFMLGLKTSF YWRICWSIVT
PFIMIAVFFY ALATTGTLTF GEDYYYPQPA YIAGDLMQYL GIALIPLFIA HALWKYRSNS
VVETVKTAFS KKPTYGPQEP ELFEEWKQFR REVKYERQQM RKNWFHHIGL SLTGGYRRGK
PKL
//