ID A0A194QKV9_PAPMA Unreviewed; 407 AA.
AC A0A194QKV9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Heparan sulfate glucosamine 3-O-sulfotransferase 5 {ECO:0000313|EMBL:KPJ06167.1};
GN ORFNames=RR48_14609 {ECO:0000313|EMBL:KPJ06167.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ06167.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ06167.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ06167.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ06167.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ461198; KPJ06167.1; -; Genomic_DNA.
DR RefSeq; XP_014370335.1; XM_014514849.1.
DR AlphaFoldDB; A0A194QKV9; -.
DR STRING; 76193.A0A194QKV9; -.
DR GeneID; 106720254; -.
DR KEGG; pmac:106720254; -.
DR InParanoid; A0A194QKV9; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF69; GH20068P; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transferase {ECO:0000313|EMBL:KPJ06167.1}.
FT DOMAIN 137..390
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 146
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 146..150
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 229
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 237
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 353
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 368..372
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 354..363
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 407 AA; 46602 MW; BBBD6FD8642F45FF CRC64;
MERIQMNQSL PGKYHRTEAS YKSCSQSLPL DILWLPRSSF RPAEGELADC VLVVGVSRPK
LAAALLSVTL LSLFLTFHVL YDSALYSIQA ASMVSAAHEN NNLLENQQMN TRTINHPMSL
RKRLKLPRPP RPVRRLPQAL IIGVRKCGTR ALLEMLYLHP MVQKASGEVH FFDRDENYAL
GLDWYRSKMP LSFKGQITIE KSPSYFVTPE VPERVRAMNS SVRLLLIVRE PVTRAISDYT
QLRSRATPSA PAHALVAGHT PHQALDAAKP FEQLAISPDG SINVAYRPIA ISLYHAYLHR
WLEVFPREQI LVVNGDQLIE DPVPQLRRIE RFLGLEHKIG RKNFYFNETK GFYCLRNDTT
DKCLRETKGR KHPRVDPAVV TKLRKFFVQH NQRFYDLVGE DLGWPED
//
