ID A0A194QLZ0_PAPXU Unreviewed; 1365 AA.
AC A0A194QLZ0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|EMBL:KPJ04471.1};
GN ORFNames=RR46_01936 {ECO:0000313|EMBL:KPJ04471.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ04471.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ04471.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ04471.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ04471.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ458981; KPJ04471.1; -; Genomic_DNA.
DR STRING; 66420.A0A194QLZ0; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF355; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 27..128
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 246..432
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 462..583
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 629..769
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1080..1326
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 521..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 415..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 698..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1365 AA; 155246 MW; 24AB97A67A7B85C3 CRC64;
MLSPKIQRSV RVNDGQLLAL SDRAQYDHSQ AGYLHKRSSD NTKWQLRWFI LYQNLLFYYE
SENNTRPTGV LLLEGSYCER LSKSPMERNA SFCFTISYRR ESQRQYELRA ASEVDCVHWV
DAIREASFNK LLLQKEELEQ KQLHLLQVVE SERTSRWQYA QQCDELTNEV KKLRTELCAY
KKEHEPATRT TSTASLSPSD SDEIDPVELR KIKKVQSFFR GWLCRRRWKQ IVDQYIKSPH
AESMRKRNSL VFKMVEAEEE YLEQMEILVT CFLRPFKMAA SSKKPPCTHE DVNSIFLNSE
TVLFLHQIFF KGLTSRMESW PTLVLGDLFD MLLPMLTIYQ EYVRNHHYSL QVLTECKQSQ
PFAQLLARLE SKPACQSRSL ETFLTYPMHQ IPRYIITLHE LLAHTPHDHV ERRSLQHARA
QLEELSRQMH DEVSETENLR KNLAVERMII EGCDILLDVN QVFIRQGTLS QVVGKGRRAS
LQARQAFLFS NHLLLTTRAT GGRLHLPPNG RLPLHDALLV EDPSSHDDDD STSVCSSPGG
DPYQGKDFKI LVEVKGEQIC AHLVAATLEE KAAWTSEVAQ CMESAALTEL LRACGSCAAS
ASLPACRSDR ALFTDDVDIR FSRTLNSCKV PQIRSATPQR LLQRLTDLRF LSVDFLNTFL
LTYRVFTDGV TVLEALKQVF YEQSQQEMEL APPPDTVRKT SGASSVSGYG SEYSDRDWQS
RFWKASRKSE DEDKLSPYLM APSRRTSNVS TSPSSPGALS SVTLVGSPKK ASPEEGSTKA
EKTSPTKDND KAAAMMKDES IELVDQSDED IKYKEEEQEK DKPKPKDEKF KISQRFSERV
RTMTESPRRL QVRGGVAEAR RRSDGARDLP APATPEPRRA SDSNAARLPR RSVSERRCTS
SSINSDRRRY FGSSEPRSSV TSQVSQMAQS YRRDTNQPKA GVVITSFRQS HRRSSTSTAA
VAFAVATSAS SNPRSPPPTS PPHNRRDSVI STAATMRVLN VLRHWISKHS SDFWSDERLR
GLTMDFLKEI EASPGLLPAE HKAAAQLLRL LERAPDRAID LKAIFAPPPI PTKESIETLS
ALEIAEQMTY LDYQIFSSIH SEEFLGQAWT KADKAERAPH ILMMTGHFNH LSNLVISEIL
KKYTLTGKKN HCPIYLLYEQ WRVAAIEKWA AVADIARCLH NFNGVLQICA ALSNTSIFRL
KKTWEKVSKT SKQTIEKMQT IISSECRFRI LRDALHRCDP PCIPYLGMYL SDLSFIEEGT
SNYTPDGLLN FSKMRMIAHV IREIRNFQQT PYKIDHIPKV CDFLLDRSLI IPEERQYTLS
LELEPRAARG SAGGLAGAPT ETASPAAQRR RRASLAALAP LRPER
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