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Database: UniProt
Entry: A0A194QMU3_PAPMA
LinkDB: A0A194QMU3_PAPMA
Original site: A0A194QMU3_PAPMA 
ID   A0A194QMU3_PAPMA        Unreviewed;      1139 AA.
AC   A0A194QMU3;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   31-JUL-2019, entry version 17.
DE   RecName: Full=E3 ubiquitin protein ligase {ECO:0000256|RuleBase:RU365038};
DE            EC=2.3.2.27 {ECO:0000256|RuleBase:RU365038};
GN   ORFNames=RR48_14722 {ECO:0000313|EMBL:KPJ06280.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ06280.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ06280.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ06280.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ06280.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
CC         conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
CC         protein]-L-lysine.; EC=2.3.2.27;
CC         Evidence={ECO:0000256|RuleBase:RU365038};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|RuleBase:RU365038}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365038}.
CC   -!- SIMILARITY: Belongs to the BRE1 family.
CC       {ECO:0000256|RuleBase:RU365038}.
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DR   EMBL; KQ461198; KPJ06280.1; -; Genomic_DNA.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010390; P:histone monoubiquitination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR013956; E3_ubiquit_lig_Bre1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR23163; PTHR23163; 4.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|RuleBase:RU365038};
KW   Coiled coil {ECO:0000256|RuleBase:RU365038, ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053240};
KW   Metal-binding {ECO:0000256|RuleBase:RU365038};
KW   Nucleus {ECO:0000256|RuleBase:RU365038};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Transferase {ECO:0000256|RuleBase:RU365038};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU365038};
KW   Zinc {ECO:0000256|RuleBase:RU365038};
KW   Zinc-finger {ECO:0000256|RuleBase:RU365038}.
FT   DOMAIN     1091   1124       RING-type. {ECO:0000259|Pfam:PF14634}.
FT   REGION        1     20       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      668    714       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      726    749       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      849    870       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      191    211       {ECO:0000256|SAM:Coils}.
FT   COILED      219    274       {ECO:0000256|SAM:Coils}.
FT   COILED      296    340       {ECO:0000256|SAM:Coils}.
FT   COILED      377    397       {ECO:0000256|SAM:Coils}.
FT   COILED      405    460       {ECO:0000256|SAM:Coils}.
FT   COILED      482    526       {ECO:0000256|SAM:Coils}.
FT   COILED      566    586       {ECO:0000256|SAM:Coils}.
FT   COILED      591    618       {ECO:0000256|SAM:Coils}.
FT   COILED      789    823       {ECO:0000256|SAM:Coils}.
FT   COILED      872    892       {ECO:0000256|SAM:Coils}.
FT   COILED      930    950       {ECO:0000256|SAM:Coils}.
FT   COILED      993   1013       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    693    713       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1139 AA;  130005 MW;  6F863487D258F759 CRC64;
     MSKRSAEDGG NGTSQPPIKK VHFEPHLIGP VSTLEEMDIK VLQFQNKKLA QRIEQRHRCE
     AELRARIEQL EKRQTQDDAV LCVVNRYWNL LNEDIRVLLQ RFDAETADES ENKNENEATT
     SFLMQLSTWD KEELDAQLAN RVQVSKRAVA KVLQAFDRLQ QRNDKIWRAI KGEGEEGAPA
     PSLDEVVRAT NEEVTAENRR LQGICTTLQE NHHAMTLRVA QLQDAVNSRD TENAELKNQI
     DDLQYELMKV RSRNDKLENH LAEAIEKLKS YHQSGASASS SSSASTGGTP LTAAAAAKLE
     DVAAELEEQR ELANNRLAEL DRLHRQHRDT LKEVEKLKMD AFDRLQQRND KIWRAIKGEG
     EEGAPAPSLD EVVRATNEEV TAENRRLQGI CTTLQENHHA MTLRVAQLQD AVNSRDTENA
     ELKNQIDDLQ YELMKVRSRN DKLENHLAEA IEKLKSYHQS GASASSSSSA STGGTPLTAA
     AAAKLEDVAA ELEEQRELAN NRLAELDRLH RQHRDTLKEV EKLKMDIRQL PESVIVETTE
     YKCLQSQFSV LYNESMQMKT ALDETRMQLQ NAKNLHMRQI EMMESEELAR QKALRAEMIQ
     LEDVLGQLRK EYEMLRIEFE QNLAANEQTG PINREMRHLI TSLQNHNQQL KGEVSRYKRK
     YKDTSQELNK LRKETEEAAA RGGASTSGEQ PDEKPPPVKK EEPDPDERLK HSRSYVRCRH
     RLVSRPSGAL HQGEWESVSE SVSDGPRPRM GSKLVGADNG HMYGEEGGMG GVGAVGGVGG
     VGVDKPASKE QARGKLHEQE QIIKELKQQL KKAVNEQKEL KLLLDMYKGV SKEQRDKVQL
     MAAERKARQE LEDHRQKAKM AQESKRERRM ADEDALRKIK QLEEQKYELQ KQLSCARPNA
     DPLHAFSRPF AGSQEEEALL NEMEVTGQAF EDMQEQNSRL IQQLREKDDA NFKLMSERIK
     ANSLHKLLRE EKQLLHEKVV TRDQQIESMG AVARRLEEKE RLLQATLSAV EKELLLRQQA
     MEMHKRKAIE SAQSAADLKL HLGYYALHYY AVQSDDCSAG GLILILFPFP PFSNKEWMGR
     ESEFGGRSDV KRKDAVLTKC FHVFCWDCLR TRYETRQRKC PKCNAAFGAN DYHRLYLST
//
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