ID A0A194QRG8_PAPMA Unreviewed; 198 AA.
AC A0A194QRG8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN ORFNames=RR48_12776 {ECO:0000313|EMBL:KPJ07934.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ07934.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ07934.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ07934.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ07934.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
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DR EMBL; KQ461175; KPJ07934.1; -; Genomic_DNA.
DR RefSeq; XP_014368056.1; XM_014512570.1.
DR AlphaFoldDB; A0A194QRG8; -.
DR STRING; 76193.A0A194QRG8; -.
DR GeneID; 106718480; -.
DR KEGG; pmac:106718480; -.
DR InParanoid; A0A194QRG8; -.
DR OrthoDB; 4175920at2759; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF2; PROTEIN LIN-7 HOMOLOG; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 10..65
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 93..175
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 198 AA; 21649 MW; 8C9EE7C2E56918ED CRC64;
MSSTGEQLTL ARDIKRAVEL LEKLQQSGEV PATKLAALQK VLQSDFLNAV REVYEHVYET
VDIQGSADIR ASATAKATVA AFAAAEGHAH PRVVELPKTE EGLGFNVMGG KEQNSPIYIS
RIIPGGVADR HGGLKRGDQL LSVNGVSVEG ENHEKAVELL KQAVGSVKLV VRYTPKVLEE
MEMRFDKQRT GRRRANYN
//
