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Database: UniProt
Entry: A0A194QT78_PAPMA
LinkDB: A0A194QT78_PAPMA
Original site: A0A194QT78_PAPMA 
ID   A0A194QT78_PAPMA        Unreviewed;       650 AA.
AC   A0A194QT78;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Nicotinate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00021569};
DE            EC=6.3.4.21 {ECO:0000256|ARBA:ARBA00013236};
GN   ORFNames=RR48_06216 {ECO:0000313|EMBL:KPJ08728.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ08728.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ08728.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ08728.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ08728.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- FUNCTION: Catalyzes the first step in the biosynthesis of NAD from
CC       nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-
CC       ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
CC       Helps prevent cellular oxidative stress via its role in NAD
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00023426}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O +
CC         nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide +
CC         phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017,
CC         ChEBI:CHEBI:456216; EC=6.3.4.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001240};
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC       ribonucleotide from nicotinate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004952}.
CC   -!- SIMILARITY: Belongs to the NAPRTase family.
CC       {ECO:0000256|ARBA:ARBA00010897}.
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DR   EMBL; KQ461150; KPJ08728.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194QT78; -.
DR   STRING; 76193.A0A194QT78; -.
DR   InParanoid; A0A194QT78; -.
DR   UniPathway; UPA00253; UER00457.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd01570; NAPRTase_A; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 3.20.140.10; nicotinate phosphoribosyltransferase; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR041525; N/Namide_PRibTrfase.
DR   InterPro; IPR041619; NAPRTase_C.
DR   InterPro; IPR040727; NAPRTase_N.
DR   InterPro; IPR007229; Nic_PRibTrfase-Fam.
DR   InterPro; IPR006405; Nic_PRibTrfase_pncB.
DR   InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR   NCBIfam; TIGR01513; NAPRTase_put; 1.
DR   PANTHER; PTHR11098; NICOTINATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR11098:SF1; NICOTINATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   Pfam; PF04095; NAPRTase; 1.
DR   Pfam; PF17956; NAPRTase_C; 1.
DR   Pfam; PF17767; NAPRTase_N; 1.
DR   SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 2.
DR   SUPFAM; SSF54675; Nicotinate/Quinolinate PRTase N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000313|EMBL:KPJ08728.1};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Transferase {ECO:0000313|EMBL:KPJ08728.1}.
FT   DOMAIN          22..149
FT                   /note="Nicotinate phosphoribosyltransferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17767"
FT   DOMAIN          417..518
FT                   /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF04095"
FT   DOMAIN          523..633
FT                   /note="Nicotinate phosphoribosyltransferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17956"
SQ   SEQUENCE   650 AA;  72119 MW;  C9856F8B88E7163F CRC64;
     MSNHDLVTNR KMARQNGIVQ PLLTDLYQIT MAYAYWKSGK VNDVAVFDLF FRTNPFQGEF
     TIFAGLEECL KFLDNFHYSD SDIDYLIQTL PDNIEPEFFA YLKDLTCKDI KLSAIEEGSV
     VFPRVPLLRI EGPLIVAQLL ETTLLTLVNF ASLMATNAAR YRMVAGKNVS LLEFGLRRAQ
     GPDGGLSASK YAYVGGFDGT SNVLAGKMFN IPVKGTHAHS FVTSFSTLED ISSVTLRHAD
     TQEQCDLLQL AVDWRRRISS IVDVSPEEAS DGELAALVSY AIAFPTGFLA LVDTYDVKRY
     TCPGPRINGH SGYNSNCGSN VDRITDSSGV RSAYGYSTVE LTLRSGLLNF CAVALALNDC
     GYRAVGIRID SGDLAYLSVL ARSTFEQIAE AFKLKWSGLL NFCAVALALN DCGYRAVGIR
     IDSGDLAYLS VLARSTFEQI AEAFKLKWFA KLTIVASNDI NEDTILSLNE QGHKIDCFGI
     GTHLVTCQRQ PALGCVYKLV EINGQPRIKL SQDVGKVTIP GHKEAYRLFG ADGHALIDLL
     QRSSEPAPII GQKVLCRHPF QESKRAYVIP SKVEHLYKEY WSEGRICVRP KPLSEVRARV
     QASLRTLRQD IKRNLNPTPY KVRCQVAVSD DLYSFIHDLW LQNAPIGELS
//
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