ID A0A194QXB4_PAPMA Unreviewed; 1179 AA.
AC A0A194QXB4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=RR48_12955 {ECO:0000313|EMBL:KPJ08216.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ08216.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ08216.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ08216.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ08216.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KQ461155; KPJ08216.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QXB4; -.
DR STRING; 76193.A0A194QXB4; -.
DR InParanoid; A0A194QXB4; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KPJ08216.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1179
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008264709"
FT DOMAIN 691..951
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 954..1081
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
SQ SEQUENCE 1179 AA; 133772 MW; 800A567387CFEA02 CRC64;
MKSLVIILLL IGLGGPVCAE KEKKDSTELS RALDDRPLLF ATLGGGMVAV EPGSGNIIWK
LKDEPVVKVP NQHANLMPQF LPDPRHGSLY MYGPRGDKQM LKKLPFTIPE LVANAPCRST
DGILYTGKKS DTWFMLDPLT GSREHISGFD KSKIFKSDED NTCEPDKRRG VYVARTEYNI
LMHDSKNENQ RWNVTFYDYT SHAMGKEMLN DYGIIHFAST SNGRIMSFDR KTGDLVWSHN
FETPVVAAYL LDREGLISVP FNSIGDDTLD HIMEDATTLR NGQGIKNSNI ELYPTLYIGE
HNHGLYALSS LVDKNTVTIS TGYTHPLLLE GPVAEIQAST ETPTYEPLSH IHYKLSDLNL
HVSPPYLLLG HYKVPELTTS WMPQLPTANL LKVPERHING MKLINGRMQA ETEKDVENET
NLKSNSISVS VQTDELFEGF GFRPDLWYKQ GYVWLHQQEN KALKVALIIL MGLVVAMFWY
LRYQAREFQQ LSQGGSRGST VSNASSQGEV TGQLVDLGDG EVRIGKITFH TDQVLGKGCE
GTFVYRGMFD KRAVAVKRLL PECFTFADRE VALLRESDAH AHVAREFQQL SQGGSRGSTV
SNASSQGEVT GQLVDLGDGE VRIGKITFHT DQVLGKGCEG TFVYRLAREF QQLSQGGSRG
STVSNASSQG EVTGQLVDLG DGEVRIGKIT FHTDQVLGKG CEGTFVYRGM FDKRAVAVKR
LLPECFTFAD REVALLRESD AHAHVVRYYC TERDKQFRYI ALELCSATLQ DYVEKKLNFE
CKIDAVEVLR QATLGLSHLH SMDIVHRDIK PHNVLLSMPT GSGEVRAMIS DFGLSKKLNI
GRVSFSRRSG VTGTDGWIAP EMINGERTTT SVDIFSLGCV FYYVLSRGQH PFGDVLRRQA
NILTGDYSLE QLDKILPEEE LVVTKILIRA MISSRPQLRP PCETVLKYPM FWGKQSILNF
LQDVSDQVES CSCAGAEHPL ERGARRVVRG DWRVHVSAPV AGDLRARRTY RGERVAHLLR
AIRNKKHHYR ELDSEVRDSL GKLPDGFVTY WLRRFPLLLP HVWVQMQQFR QEDILQAYYP
HSYAFNRDDV YELTDEDIEE PQEVRDPDKN ELFLKSRIYF DEKKDQERFY RYKSPKKIVD
WRNESSNLRL QDDVRLRDRF YKKKEKKKDE FPIWTLPPQ
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