ID A0A194QYB2_PAPMA Unreviewed; 516 AA.
AC A0A194QYB2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Galactose mutarotase {ECO:0000256|ARBA:ARBA00021023};
DE AltName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00032729};
GN ORFNames=RR48_08949 {ECO:0000313|EMBL:KPJ10289.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ10289.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ10289.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ10289.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ10289.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose = beta-D-galactose; Xref=Rhea:RHEA:28675,
CC ChEBI:CHEBI:27667, ChEBI:CHEBI:28061; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001712};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28677;
CC Evidence={ECO:0000256|ARBA:ARBA00001712};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206}.
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DR EMBL; KQ460953; KPJ10289.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QYB2; -.
DR STRING; 76193.A0A194QYB2; -.
DR InParanoid; A0A194QYB2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..398
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 57115 MW; 0DFD5EFF18DCA43E CRC64;
MADEVDDKAS GDVASEASEE KSVIPEPEPI KVPDVELTVD GFGFMSKQSS IDKSKKNGRR
KSKELKEILA PEAEASPCSS SSNIDIVRRF TWKTKNRMTV QVITYGATIT TIQVPDKKGV
PDDVIAGFDT LEEYFQPRNP YFGATIGRYA NVIRNATMSV RPMGRMYMLS SNLGPNHCNG
GYVGFDKVNW RSHVVGNKVY MSHVSDRFHE GYPGTVMTQL CFEVTCDNTI NIEMKCTTTE
PTIINLSNAQ YFNLAGHHRG AESMYEHIIT INADKYTQVD DDGLVTGEKK VVGGTAFDFR
VPRCLKTMLP KIPKGGYDVN FCITQATAQD LTFHARALHP DTGRVLEVYS NQPGLQFYTG
NRLPDPDRIV AALSGGEEEG AEQSESEASA EDEEFRDVDG GSDNQGDGKE HYGYVPLAGK
NGTFYKKHGL FCLLPQNYPD AINHRRSVLK RKCAVRFVDE ACSSRGLAVR CSLARPSALN
IRHSRSDACE ARTVPTHSPQ RAQNLEPFQS RSNLPP
//
