ID A0A194R0D5_PAPMA Unreviewed; 4088 AA.
AC A0A194R0D5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Dynein heavy chain 6, axonemal {ECO:0000313|EMBL:KPJ09301.1};
GN ORFNames=RR48_15442 {ECO:0000313|EMBL:KPJ09301.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ09301.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ09301.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ09301.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ09301.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KQ461108; KPJ09301.1; -; Genomic_DNA.
DR STRING; 76193.A0A194R0D5; -.
DR InParanoid; A0A194R0D5; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT DOMAIN 1410..1512
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2034..2182
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 95..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 643..670
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2861..2909
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4088 AA; 462407 MW; 6161AB54782076C3 CRC64;
MNDTKRRSTI TLPAIETIQR NVRQVPTIYS RKPRDIPFHL PHRKLLEKIE FVEKEPEPLT
GFAAAQEDRY TRERKSAKIQ LEPIKHEEVK KKKAIKIRES RSSMDDERKE EPTADPLKLK
PQVASQKEVI DHVRSNPQCG FLYMIYAVHP QNVYFTPYYL KVVKYEDLDR KNYFTISPCG
VTHYTSEMVF TKLNDWEQEY TVFVQLHEIT FFKVYRYWKA LYVWHKSVRF RKYSRLRSVL
SRQLFLLTPP LARALLTVQA LCCRMLEVSL ADTTRHMDTP FFYFNEAQMI RLEMVRRRIT
EFRSVAHEAV TVAGHEALRL RGFTVDDHEV PPPAIVRGRP VGGMSYTQKA NKRKYCERLA
CFIKLVDYMT NYMLHGLTNR SNAHMANLLR THASFTPSHD LLTSLDVDTV LEVVPRPVEI
CKWALFQVDA YVLPSGEVEL NPSEKIISEY ISKVTEYWDE VVRTFHNFLN DDDLQMFVQP
TIMGKQVEWS AGVSPNLYFL MNQDKKMLED ITYIPTAIKE AFGVVDVFLN RMKTFMVEFK
AAHEMDLNLI RDERDVNAFK LLCDKLVKQM ETIEDVVSYQ PLGIIFLNLC PFQELFRPQP
RRLFDVVLNT TPDVGRACID EILEGIESIS ADISREPETA AELVEFNSLL DGLESRVAFL
EERLEYLREL YDFMGEFNIP ISPEDMTDYL GLSVALGTLR TSVDARLETR GKLAGQFASQ
VGRDLMQLME EVNTLHAQVA QPWLYDDSSD MAKVIEVLDD LMSKLMVCFA RDKQIHEWQK
IFKIPPSRLD QLDEAINDVK LRQMLWKSSK EWDDHYRSCR LVSLLRHLIH RYEAPFNTLD
VDEIQTAAVN YGKQFNQMDK ALPPNKIVPR CKQSIDVMKD KLPVISYLRS PALKARHWVR
VEEVLHTRFV PGVPLTLADL EQLGAFQHAE ELMEIAAQAN SEAGLEALLK KVEETWAALE
FPVLPHKDSR DVFMLGGLEE VQAALDESCV NVNTILSSRS CGPLKSRVEE WQRNLELFGK
TLEEWQQCQQ TWMYLEAIFS APDIQRQLPN ETRLFTIVDK SWKDNMRKVA KVPLALPAAT
QPKLYEELVR NNEMLDQIMK CLEAYLETKR VAFPRFFFLS NDELLEILAQ TRNPHAVQPH
LRKCFDAIAK LEFGVKLPES EMEVAEDGTL VEREMSPRSR DRLQAALALT ARPEDLTTDI
VAMLSPESER VNLGKGLKAR GNVEEWLGKV EAAMFASVKR CMKYALRDYE MRPRPQWSAL
HPNQVVLTVS QIMWARGIHE VLSGAEGEDV TTGLAEFERR SVGDLNALAA LTRQPLGALF
RRVLCALITV DVHARDSVSN MVEKRVQKDT DFEWLKMIRY YWEEELDNCV ARMSSAMYIY
GHEYLGAGGV LVITPLTDRC YLCLMGALQL DLGGAPAGPA GTGKTETTKD LAKAVAVQCV
VFNCSEGLDY KMMGRFFSGL ATSGAWCCFD EFNRIDIEVL SVIAQQLITI RNAKIARLSR
FMFEGREIKL VRTCAAFITM NPGYAGRTEL PDNLKALFRP ISMMVPDYAL IAEVILYSEG
FESSKVLARK MVQMYKLSSE QLSKQDHYDF GMRAVKSVLV MAGALKRANP DQVEDLTLLC
ALNDSNLPKF LAADALLFAG ILSDLFPGLE LPVRDYGVME EAIKYCLLER NLQIEACQIR
KVIQLHETMI VRWGVMLVGP TGGGKTVVLH VLGETYIRLH EQEVEGPQNK PVHMYTMNPK
SLSIGELYGE VNLQTLEWHD GVLPLSLRIA VQCTATDHQW IICDGPVDAV WIENMNTVLD
DNKMLCLANS ERIKLTPHVH MLFEVGDLAQ ASPATVSRCG MVYVDPREMG VLPYARSWIA
GAAAQGLLTG DHPDFLYQMF LMLPEGLDYV TDKCTVGIKQ VDASKVAALC SLLGSLLAEP
GERFPDKSAA RSYLALCYQF CYAWAAGGNL LESFRRPFDE FIKRQFETFE EGEYLPTGMN
LFEVYVDTKL RRARPWSEST PPFTYDPDRP FFETLVPTTD TARYGHLLRR WLATNRPTIF
TGDTGVGKTC IILQVLNKMQ TTDSFIPVTL NFSAQTSSKK TQEAIEQRLE KRPRRALGAP
LGRRIVVFVD DVNMPRLDIY GAQPTIELLR QFLDFGGWHD RDKLYWKEII DVVVVAACAP
PGGGRNPLTA RFVRHFAMLH VAAPDSSAMI TIFKSILGGH MEDFVTEVSS LADNLVRAAV
EVYGRVCAQL LPTPARAHYV FNLRDLSKCV QGALQARAAY VRVPREMLRL FYHECLRVFH
DRLICVEDKT FFYRLMCDVC EKNFKEPVLE LPEGELIEEP PMLLFGDFIN PSLPKEMRVY
RELPDMEKLM AVLKEYLDEY NASARTEMRL VVFSEMAEHV TRVARVLRAE RGHALLVGPA
GSGRRSVAAL AAHLNDCRCM GMELKRNYDV PEFHEDLVKM YMSAGVALRE TVFLCTDSQL
SRDDFLEDVN NMLNTGEVNN LLEGDAYEQM QSGCGQDAAK AGVNLSDRDA LYRFFINRVR
AKLHLCICMS PVGEGFRRRC RMFPSLVNCC TIDWLTKWPP GALHSVARQS LAPLGDAKLI
NDVSTVCVSM HQDVDVMSER LFTELRRHFY STPSSYLDLL QLYLSLLDAK RQEIISGRDR
VSCGLEKLYS AYESVGAMER AVREMEPLLA RKAAEGSALA ARLQNERRAA DLVRSALLVD
EANAKMKADE VRQIADEAKA DLALAMPAME AAQDALKALN KADINELKAF QKPPTLVRFV
MEPVCILLGA KPDWDSTKKL LADVNFIRNL QEYDKDHIPD ATLKKIKTYL THKDFNPDTV
VKVSKVCRSM VLWVQAIDMY AKVFRVVEPK ILKHKEAAGI LRSVMAELRA KQKQVEAVEA
QLAAMQRELE IVEEERDRLQ ADVQLAAARL ARAGSLTQAL ANEQSRWENS VKEASLQLID
ATGNVLVAAG CIAYFGAFPA HYRRELEHKW VAHCAELKIP ASPTFDLVGT AAGPGARLAW
QSQGLPRDAG SAENATLVVS AGRRPLAIDP QQQANRWIKN MERENGLHVA KPTAPNLLRI
LESCVRLGWP MLLEDVGEEL DAALTPLLLK QTFIQGGRLL IHLGDSDIEY DPHFRLYLTT
KLGNPHYLPE ICIQVTLVNF TVTLSGLEEQ LLAEVVSLER PELELQRTQL TQRIAADRTL
LLDIEERILH LLHASTGNIL DDEVLIETLN ESKETSEIIS ARLAEAEITE RSIGAARERY
REVAARGALL YFAIAQLADL DPMYQFSLSY FTQIFKRVVE EPAKEGDTLE MRVAALVDSA
TLATQRAVSR ALFARHRLAL SMLLTAAVQL HSGALPHSYW HYLMHGAGAP AGGMPKKPAT
EAITEQTWAA VNFLHEHEPA FTGLPDDCLK RIPLNVGEYF VEIHVDKTNT SKPTVDWDKR
LSPFEKLMLL KCLREEKLVF ASSQYVSLTL GPAFIESPPV QLPTLYADTN STTPLVFVLS
TGSDPFGAFQ KFATDKGMRD RVNFISLGQG QGPVAEKMIS DAKPKGDWVF LQNCHLAASW
MRNLELIVES FTSDQSPIHE EFRLYLSSMP TPKFPVSVLQ NSVKVTNEPP KGLKANVKRA
LIEMDTDFYE NHVLEQDWRT LVFGICIFHA LVQERKKFGP LGWNISYEFS DSDRECAILT
LQMFCAGGEI PWDALEYITS EITYGGRVTD MWDQRCLAAA LRRVVSRAAL SPEHSYSPCG
RYACPRVPLL ADAQRYVDSL PDNEPPGLFG LHDNANITYE RQETTALLQT IAEVQPRSGG
AGGEPPERLV WRICESTRAS VPHKVDTSIT HESVFAVDER GQPLSLATVL HHERKQYDTL
LTLLHSSLRE LQRAVQGVVV MSEALEEVFN ALANGRVPAM WHARAYNSLK SLGSWLHDLA
LRVDFIETWW RKGRGASSWL PGLFFPQGLL TGALQTHARR NRLPIDVLAF DFHPTSVFIY
QDDIYAFNKH PKEQVDVYSG LEAPDEGIII HGLYIEAGRW DVPNACLADA LPGQTWSWLP
AVRVSCRVGA PPAGGRYEAP LYRTAARAGV LATTGHSTNF VIAILLPADH PSDFWILRGT
ALLTQLSD
//
