ID A0A194R2Z7_PAPMA Unreviewed; 2109 AA.
AC A0A194R2Z7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Myosin-VIIa {ECO:0000313|EMBL:KPJ11894.1};
GN ORFNames=RR48_09831 {ECO:0000313|EMBL:KPJ11894.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ11894.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ11894.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ11894.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ11894.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KQ460855; KPJ11894.1; -; Genomic_DNA.
DR RefSeq; XP_014362715.1; XM_014507229.1.
DR STRING; 76193.A0A194R2Z7; -.
DR GeneID; 106714246; -.
DR KEGG; pmac:106714246; -.
DR InParanoid; A0A194R2Z7; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 64..733
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 961..1188
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1193..1504
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1502..1569
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1645..1793
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1799..2103
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 612..634
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 157..164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2109 AA; 242446 MW; 7DC9ED6BB595862E CRC64;
MADRIRLSDL VWLQPEGKSE FDIPIAVKIL NSSGGLIQVQ DDDGKVFSTS VNNVIKPLHA
TSVQNVEDMI TLGELQEHTI LRNLHIRYNR QLIYTYTGTM LIAINPYEIL PIYTMDQIHF
YQDRNVGEIP PHIFAIGNNA YKELLGTSSN QCIVISGESG AGKTESTKLL LQYLAAASGK
HSWIEQQIQE TNPILEAFGN AKTVKNDNSS RFGKYINIYF NKQGVIEGGN IDQYLLERSR
IVFQNRGERN YHIFYSLVTG LSADEKKKLE LGRPSDYVYL NSGNMLTCDG RNDALEFADI
RSAFKVLNFP ENEVWGVFSL LAAILHLGNL KFKSFNLNNI DSSEVADTTN ATRIANILGV
NKATFCDALT KKTLIAQGDK VVSTLSVSAA IEGRDALVKA IYGHVFEYIV ETINKTLCKG
QQLSSGSVGI LDIFGFENFL SNSFEQLCIN YANENLQQFF VRHIFKIEQE QYQKEGITWT
NINYVDNQIN LDMIGLKPMN LLSLIDEESR FPKGTDITLL SKLHSNHSNN TSYVTPKSTH
EHRFGVRHYA GDVYYEVKGF LDKNRDMLTS DVKEMIMDSN NDFLKSLFPM ESVSQSGSRK
TVSLSYQFKT SLDALMKTLY ACHPFFVRCI KPNEHKKPRL FDRTLCVRQL RYAGLMETAK
IRQAGYPIRY PYTEFVHRYR LVVDGIPPAE KTDCIAAAKK ICNEILKDED FRFGHTKVFM
KDHHDVILEE IRHTVILRSV IKTQANIRRF IQRRKYLRMR AAAITLQKHF RARGYRNRYL
ILRRGYLRLQ AVIKSRELRR TFLNLRKFFT NLQAHCKGYL VRKLVKEKGD IIRAKLAELH
MEKEELILVN NDVQAAENEY EKKFDDIMRS IWITKEATES NTQNAEGIDD KYVDDVFGFL
KDTSTPAGTV RGTGFGVTLT EKQSTDEVIP LRQELQEEPF DAFNYRKFAA TYFLGNTSHQ
YSRKPLKNSL LDLPSPIDNV AAQALWITIL RFMGDLAEPK YVDDKIDNIP VMTKLTDTIG
RAFQKSKEFE ALIQPERSTN SSSKIVQKSI KRRAKMNEEF MRNIMNDDST NEMYHDWLHS
RRSTNLEKLH FIIGHGIIRK ELRDEIFCQL CKQLTNNPSK SSHARGWILL SLCVGCFPPS
ERFVKYLRSF IRDGPPGYAP YCEGRLMRTF KNGARTQPPS WLELQATKTK KPILLTVTLM
DESMKTVQSD SATTSEEICQ QIADNIGLTD VFGFSLYITL YDIVLSLGNE NVHIMDAVSQ
CEQFAKEQGT PEKNAPWRLF FRKEVFTPWH NPAEDPIATN LIYYQVAKGV KFGEYRCNSE
KDLAMLAAQQ HYIEHGDRLD PNVLRKVIVN YIPNQFIKSN DVALTKWEHL VTKAFESAKS
IQSKVDPLRC KEDIVIFAKL KWPMLFSRFF EAVKLKGDSI NKDIIIIAVN WTGIYIVDQL
EHILLEISYP EITYVAYDDD EEYDNVGRVT IRTIQQEEFV FQSVDASELS SLMIYIIDGL
KRRSTYVIAQ MDSQGYSDAA SFLQYKKGDL ITLLHDCTGE TLMNSTWGHG SCNNQEGLFP
TEQVYILPTL SLPSDVILDT FKKGNINTDK KPLSKYNTLQ RKRMHTLENF AKEYFRENTD
FNTTISKQST LNTAKKPLVI DLWAHSRENL KKPLLKKLIG DEKLSKHALT AFYAIQKYMG
DLPAAKPRSA TEYTDEIFKA ALTEPSLRDE IYCQIMKQLT NNRIQLSEER GWELMWLVTG
IFACGQILIK DLVEFLKTRP HPIAKECLKR VFKTQKHGPR MYPPYVIEVE AIQHRSMQIY
HKVYFPDDTD EAFEVDSSTR ARDLCEQITG RLNLKNSDGF SLFVKIADKV FSVPENYYFF
DFVHELVEWM KRSRPVRSAG SQVQMNYQIF FMKKLWINTV PGKDKNADQI FYFPQELPKY
LRGYHKTSKQ DLVELAALIY RARYGDDQTG LTQITQILED LIPSDMTRIQ TNSQWKSSIT
AAYLRHGNMT EEEAKEQFLK KIYQLPTFGT AFFEVKQTSD PTYPEMVVIG INRNGVSVIH
PQSRDVLVTH PFSQLSNWSS GNTFFHMTMG NVLRGTKILC ETSLGYKMDD LISSYIAVLR
QAVRQKSRP
//
