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Database: UniProt
Entry: A0A194R529_PAPMA
LinkDB: A0A194R529_PAPMA
Original site: A0A194R529_PAPMA 
ID   A0A194R529_PAPMA        Unreviewed;       600 AA.
AC   A0A194R529;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4 {ECO:0000313|EMBL:KPJ12787.1};
GN   ORFNames=RR48_10417 {ECO:0000313|EMBL:KPJ12787.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ12787.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ12787.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ12787.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ12787.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; KQ460685; KPJ12787.1; -; Genomic_DNA.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 2.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 2.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 2.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053240};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:KPJ12787.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     84    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    192       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      200    242       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   DOMAIN      259    431       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   600 AA;  68747 MW;  6734D68572EC9F4D CRC64;
     MSGLKRCISQ VSMFMTGKPI NSSESAWREE LQKYRQARYA ARRVRKRVIF KHGDCNVVQW
     NVAKRRRRYL QDIFTTLVDA QWRWTLLVFA LSFILSWLLF ALIWWLIIFT HGDLNPPPPN
     STSEFIPCLN NVNSFTGCFL FSVETQHTIG YGSRTTNEEC PEAIFVMCLQ SIVGVFIQAF
     MVGTVFAKLS RPKKRAQTLL YSRNAVICLR DGQLCLMFRV GDMRKSHIVE AHIRAQIIRR
     KVGLIFAKLA RAKKRNTTLL FSRNAVICLR DGEFCLLFRV GDIRKSHILE AHVRAQIIRK
     KMTREGEVLP FYQQELKVGA DGEEDRLMFI WPMTIVHKIN EKSPLYNLSA SDMLRERFEI
     VVMLEGVIES TGMTTQARSS FLPSEILWGH RFETMVSFRK DTGEYEVDYT RFNNTYEVDT
     PLCSAKQLDE LRATVSTSQK LDRMLGTIPK TFSNDTLDLS SVDSISLDEH IEIKIPEARV
     RENRLMAQNN FVQHVNEKLK NHSHLAVENG QVPLPKNLSM TGMNIETKAD NVQTKDGNIH
     RSHSHASMKR AHGLTPNGVG HHGPEKDHKI KKTPSDHHIV EKIPVHPIPI LVTSPAPEPA
//
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