ID   A0A194RAN7_PAPMA        Unreviewed;      1153 AA.
AC   A0A194RAN7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KPJ14559.1};
GN   ORFNames=RR48_13630 {ECO:0000313|EMBL:KPJ14559.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ14559.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ14559.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ14559.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ14559.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ460473; KPJ14559.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194RAN7; -.
DR   STRING; 76193.A0A194RAN7; -.
DR   InParanoid; A0A194RAN7; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:UniProt.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd07225; Pat_PNPLA6_PNPLA7; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          130..257
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          503..585
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          742..912
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          277..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1126..1153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  128155 MW;  8E7FF365D38508BF CRC64;
     MDVVGLLNNI NDKSDMFAVK TWTAEWSKLS GGTGAIDAGG EPAKRFRKRD KMLFYGRRML
     RKVKSISNSG QGRKRRAVMR FARKLLQLKK EAAPEQLKVL EPPAEYLEED LTSDDRVPPD
     ALYMLHSIRV FGHFEKPVFL MLCKHTEILN LPAGSFLFKV GDTDENVYVV QTGRVNVYIT
     NPDGSSLSLK VVRAGESVTS LLSFTDVLTG HSQPYKTVNA KALEDSQVIK LPMRAFQEVF
     KEYPDIFVRV IQIIMVRLQR VTFTALHQYL GLSAELVNPG KDKRRPGTVS SPGKSSKVVL
     VDSGTTMHPH NHSTQSPHHE RVEHMEGGHQ TSSPIHIQGR RPRPDMVPDL TSNTPQALIQ
     IASEAFVKEL GLENDTLVRG NVQVRDLPAG TYIMKEESHK SFRLLYLRQI SSRFAEPSRR
     YLLTSIHPSK PGEVEGGLAV LTGEPSFFSI RAKHFSRIGL LSKTTVYSIM RERPSVVLHI
     ANTVVKRLSP FVRQVDFALD WVFLESGRAV YRQDEESGST FIVLSGRLRS VITHPNGKKE
     LVGEYGKGDL VGIVEMVTQT RRSTTVMAVR DSELAKLPEG LFNAIKLRFP VVVTRLINLL
     GHRILGSWQK PGGAGRGPAA LEPRSSQHTF STVAVVPVGD DVPLTAFTYE LYHSLSAIGP
     TVRLTSDVIR KLLGLTIMDP NNEYRLSSWL AQQEDKHKVA LYQCDPSLTQ WTQRCIRQAD
     CILIVALGDK QPSIGKEAGI PIDMVGGVSI GAFMGALWCM ERNITTEAGI PIDMVGGVSI
     GAFMGALWCM ERNITTVTQK ARDWSQKMTQ WGKQLLDLTY PATSMFSGRQ FNATIRGTFG
     DVHIEDLWLP YFTVTTDISS SCMRIHRHGS LWRYIRASMS LSGYMPPLCD PVDGHLLLDG
     GYVNNLPADV MRSLGAKHIL AIDVGSQDDT DLTNYGDDLS GWWLLWKRWN PFTTPVKVPN
     LPDIQSRLAY VSCNRQLEEV KSSDYCEYIR PPIDAYKTLQ FGSFDEIREV GYRHGAAYFE
     GQRRGGGGGV SGVGATPRAQ PAQPALTDYT FTDLAQMVCS VRTAQEVDNS SSSSSDYEED
     QRHFEGYASE PSAGILEMSS SVEEGAAWMG GHSDTELEGL RTRRVGGSLS LSEDEIDSEA
     EVYDPLNKRG GNR
//