ID A0A194RDU7_PAPMA Unreviewed; 460 AA.
AC A0A194RDU7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Endophilin-A {ECO:0000256|ARBA:ARBA00018286};
DE AltName: Full=SH3 domain-containing GRB2-like protein {ECO:0000256|ARBA:ARBA00030140};
GN ORFNames=RR48_09700 {ECO:0000313|EMBL:KPJ15777.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ15777.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ15777.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ15777.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ15777.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Required presynaptically at the neuromuscular junction.
CC Implicated in synaptic vesicle endocytosis.
CC {ECO:0000256|ARBA:ARBA00003037}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
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DR EMBL; KQ460325; KPJ15777.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194RDU7; -.
DR STRING; 76193.A0A194RDU7; -.
DR InParanoid; A0A194RDU7; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd07592; BAR_Endophilin_A; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF30; ENDOPHILIN-A; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..252
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 397..456
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 274..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 51300 MW; 918B29003F214216 CRC64;
MAFAGLKKQI NKANQYVTEK MGGAEGTKLD LDFVEMERKT DVTCELVEEL QTKTKEFLQP
NPTARAKMAA VKGISKLSGQ AKSNTYPQPE GVLGDCMLLY GKKLGEDTVF SQCLIEMGEA
LKQMADVKYS LDDNIKQSFL EPLHHLQTKD LKEVMHHRKK LQGRRLDFDC KRRRQAKGAH
IADEEIRQAE EKFAESLQLA QIGMFNLLDN DVEQVAQLSF FAEGLLEYHQ QCTEILKGLV
STLMEKKEEA VNRPKMEFVP KTLADLHIEG VHDLNNGRRY GSTQSLSRPR NHIPPSSSVG
DLSVDPLRAW DLPRPEPRPE QRSMSRPALG FRPHPAPRQY NGKDPWTEGG SHAGSPDHKP
PSNLELFPGA GNAPRSNQAS PLPSPVKSPA RTPMAPAKGP CCTALYDFEP ENPGELGFKE
NDVITLISKV DENWFEGSVN GKTGYFPISY VQVTVPLPNM
//
