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Database: UniProt
Entry: A0A194RGP8_PAPMA
LinkDB: A0A194RGP8_PAPMA
Original site: A0A194RGP8_PAPMA 
ID   A0A194RGP8_PAPMA        Unreviewed;       500 AA.
AC   A0A194RGP8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=Neuronal acetylcholine receptor subunit alpha-7 {ECO:0000313|EMBL:KPJ16762.1};
GN   ORFNames=RR48_10361 {ECO:0000313|EMBL:KPJ16762.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ16762.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ16762.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ16762.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ16762.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; KQ460207; KPJ16762.1; -; Genomic_DNA.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053240};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128, ECO:0000313|EMBL:KPJ16762.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   TRANSMEM    235    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    494       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    234       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      241    490       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   500 AA;  57024 MW;  DE1B4E3E564C2907 CRC64;
     MEKKEASTTD GGYREESEVR VRCGYHEKRL LHHLLDHYNV LERPVVNESD PLQLSFGLTL
     MQIIDVDEKN QLLITNIWLK LEWNDMNLRW NTSDFGGVKD LRVPPHRLWK PDVLMYNSAD
     EGFDSTYPTN VVVRNNGSCL YVPPGIFKST CKIDITWFPF DDQRCEMKFG SWTYDGYQLD
     LQLQDEAGGD ISSFVTNGEW ELIGVPGKRN EIYYNCCPEP YIDITFAVVI RRKTLYYFFN
     LIVPCVLIAS MALLGFTLPP DSGEKLSLGV TILLSLTVFL NMVAETMPAT SDAVPLLGTY
     FNCIMFMVAS SVVSTILILN YHHRHADTHE MSDWIRCVFL YWLPWILRMS RPGSATTPPP
     ARAPPPPDLE LRERSSKSLL ANVLDIDDDF RHAHAQQPPC CRYYRSLDDL HEHYSPGGEE
     NGAGLAAHSC FGVDYELSLI LKEIRVITDQ MRKDDEDADI SRDWKFAAMV VDRLCLIIFT
     LFTIIATLAV LLSAPHIMVS
//
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