ID A0A194RGT2_PAPMA Unreviewed; 692 AA.
AC A0A194RGT2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN ORFNames=RR48_13884 {ECO:0000313|EMBL:KPJ17028.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ17028.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ17028.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ17028.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ17028.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. May promote
CC termination of transcription by RNA polymerase II.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
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DR EMBL; KQ460205; KPJ17028.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194RGT2; -.
DR STRING; 76193.A0A194RGT2; -.
DR InParanoid; A0A194RGT2; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 2.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 3.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..255
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 324..499
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 547..685
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT REGION 438..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 79985 MW; 2B38EA11DE76F625 CRC64;
MGVPAFFRWL SRKYSSVIVE CVEERPTDVD GELIHIDSSL PNPNGVEFDN LYLDMNGIIH
PCTHPEDKPA PKDEDEMMVA IFECIDRLFR IVRPRKLLYM AIDGVAPRAK MNQQRSRRFR
ASKEIQEKIE EVARVRSELL AKGAYLPPEK PKEAHFDSNC ITPGTPFMDR LSKCLHYYIH
DRLNNDPGWK SIKVILSDAN VPGEGEHKIM DYIRRQRAQP DHDPNTQHVL CGADADLIML
GLATHEPNFT IIREEFKPNK PRPCDVCGQL GHEMKECTGT TPDASVVRSD PAFGAQDNFI
FVRLSVLREY LEKELQMPNL PFPYDFERAL DDWVFMCFFV GNDFLPHLPS LEIREGAVDR
LVNLYKKCVY KTKGWVTDSG DVNLERVQVI MDELGRVEDE IFKRRHHNEL VFRARDKARK
KQQQVNFKLL EKTQFAPMQE GSERRGRKRT AAEAEVEGGS EAEVEEDEDK HDEVRLWEDG
FKERYYESKF EVSSDNMEFS AFPPHSAISK IVFCASIRVE LRAAKICESS TAHYVPTERF
GAYPKYRVAL QYVRGLCWVL RYYYQGCASW KWYFPYHYAP FASDFVNICG LSTKFEKGTQ
PFRPLEQLMG VFPAASSSHV PQPWAKLMSD PFSPIIDFYP TDFKIDLNGK KFAWQGVALL
PFVDENRLFK ALEPYYKDLS QAESKTSIHT II
//
