ID A0A194RK59_PAPMA Unreviewed; 1356 AA.
AC A0A194RK59;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 28-JUN-2023, entry version 26.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=RR48_06620 {ECO:0000313|EMBL:KPJ17814.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ17814.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ17814.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ17814.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ17814.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KQ460106; KPJ17814.1; -; Genomic_DNA.
DR STRING; 76193.A0A194RK59; -.
DR InParanoid; A0A194RK59; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR032628; AC_N.
DR InterPro; IPR009398; Adcy_conserved_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF1; ADENYLATE CYCLASE TYPE 8; 1.
DR Pfam; PF16214; AC_N; 1.
DR Pfam; PF06327; Adcy_cons_dom; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 391..518
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 965..1101
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 55..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1356 AA; 153890 MW; 6F86428F9AC04698 CRC64;
MHNTIHIAEK GTEWKNTLRE MLSYPQEFGN DVQRKRARDI YGLCCEVVRE GDCEAAPDSE
RLPGDGASCS APDDQHRISD EDGSSNSPRN SIDPFRTESD PVSSESILRT GRYYKGIYWP
SITNSFKDET VELSYQRYSR RQRQKSLIMV NVVDLALKIC LSLIYTLTNR HDIESVADGY
QIAWTVAFAC LNVAVCLLGC WRCFANNYLH WAAAATWILL IAQGLSGQGI GFQAPENQVW
YMLFIIFAPY AMLPLSLGWC IVIGLLSSVS HVLATAVVIK DIMNNSAEVA QSCAIRLLVA
NALLYNAVNF AGMYAKYLTD WGQRKAFLET HRSMVTRQRT KRESDRQWKL FQSVIPDFLA
KEIYSHVSRV KGEFQEQQFN NLYIQRHENV SILFADIKGF TELSSKCNAQ ELVKILNELF
ARFDRLATEN HCLRIKLLGD CYFCVSGLPE RRSNHAYCCV NMGLHMIRVI RDVRYNAQVD
LDMRIGVHSG AVLCGVLGLL KWQFDLWSLD VTIANHMESG GLPGRVHISS ATLECLNGTF
EVEAGEGETR DPCLRELGLT TYLIKSSEQP RRTRHRSRPN CIQAVPQAPC DTPRRTSSSI
DDENTTDWTP EMPFQSYFSS SSAIVTRLPC LIKREDAEQG QDVEITSMSD EDDIINHSIE
VSSNRRMRLD NMRSWSLRFR RASLEQRFAS QDERTFKSNV MCCLVLWLFI LAVQYVIHFN
CWKLVAILGV MTVPLALSFC LVMAEEFPGV APRVARVSAA LGRSRLRRNL HICGFVTIMS
ISSTTKLYIC PSSFRNATSS LERPNGTDTE HERAGECYRP EYIVFTWILC LVALTSILKL
YYLIKTLLAV LNVAMFSVLL LLYYNEYDFN SLNRSTQLPF YVQMLILMVM FLVMVVYHAR
LVEVTSRLDL LWRLQAQTDL AEMRDTQRTN RHLLKHILPD HVVAHFLAKD RCPDELYSQW
RDEVGVMFAG IPNFHEFYSE QKAIDCMRLL NEIIFDFDKL LMQPRFKSIE KIKTIGATYM
AASGLNPNHK SGQDECEHLC ALVDYAFALR EALDDINKHS FNKFRLRVGI SCGPLVGGVI
GARKPVYDIW GNTVNEASRM ESTGAMDRIQ VTKYTKQVLE RRGYGLEARG LVEVKGKGRM
ETWWVRRRRA RGAGPLPAPA PPRSLAALVY TMLQARKRIY THPLDTPAIS SSRAGSVRAE
RRAPKRHTHT NGQKMEMGIR PHASSMVVRR PDMAPPIMGS ASAPHTPTAP HAPQAPQPAA
PQPHMSEPRL GIGARLKAAS FSYRTRPARE RDRSPRLRDQ TEGSTGSVAN GTPGSFRFRS
VTTASFFRSR NRDRRNKEQV DEDAKENGDT HVTTRM
//
