ID   A0A194RL64_PAPMA        Unreviewed;       758 AA.
AC   A0A194RL64;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Nephrin {ECO:0000313|EMBL:KPJ18060.1};
GN   ORFNames=RR48_11908 {ECO:0000313|EMBL:KPJ18060.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ18060.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ18060.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ18060.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ18060.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
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DR   EMBL; KQ460045; KPJ18060.1; -; Genomic_DNA.
DR   RefSeq; XP_014371934.1; XM_014516448.1.
DR   AlphaFoldDB; A0A194RL64; -.
DR   STRING; 76193.A0A194RL64; -.
DR   GeneID; 106721504; -.
DR   KEGG; pmac:106721504; -.
DR   InParanoid; A0A194RL64; -.
DR   OrthoDB; 5358399at2759; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR23278:SF19; OBSCURIN; 1.
DR   PANTHER; PTHR23278; SIDESTEP PROTEIN; 1.
DR   Pfam; PF08205; C2-set_2; 2.
DR   Pfam; PF13927; Ig_3; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..758
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008265293"
FT   TRANSMEM        652..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          19..134
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          142..236
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          242..342
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          349..439
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          444..527
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   758 AA;  83966 MW;  3641AEA962AD0819 CRC64;
     MDRRMRVFGA LIFLIIVSPT LAFVAGADGP VLFQEALENG ESTLSCDSSP DTAEDEIMLL
     VWYKDNESIY SYDARVGTEW CNIGFNASGR VIANMSSNPT TLTITALRDD DQALYHCRVE
     FLLSPTRNTG VNLTVIVLPS EPFFLDELGN TVTNKTRPYY EGDTLVLTCL VIGGRPPPKI
     TWYSGDILVD ASYSVSDIPN VRQNELYLPL TRDNADTLSC RATNTHLVKP LKANLLIELY
     LPANNVTVEW IQETTNGNIR SGDTVIVQCI AYGSYPIPDI TWFLNHKSLS HHSNQTWNET
     LQAVTSRIAL TPTRVDNNAT LTCEAKNPVM PAGRNSKSAS VSLNVTFGPV VHVTRFEDEK
     NEVIELDTLI LKCKVEANPP ASKLFWYYND IEIKDGIRGI RVSSNALVID EVSRSDSGRY
     SCAARNNIGE TKASPINISV LYPPACTKLG IVLKKETFIC NVKGLPTPDT YFWHINQVDY
     DAQHLTTGSN TLSLEQVAGP FSESLNVSCE ADNGIASQDK SCNRVIRIGH LKPQQPQQCD
     LAFEYKEFQI RCLPVENATY YELSLWRLST TNTSLVLDQK RSLEVGNSLA LMQNEEPWLV
     RGELGLLKAG DEAGAAACNR YGCSAALLLR PTEGLLSAAM PPWWKFFTER DIGISIGVLL
     LVVMFVCSTV LAVRLAKRSR TKPVPVIQVL QLDDVTRDYL SRTSDIHGLP SCSLRSNSSD
     YSEDGDSPSL ADCRYPHIPQ DWIPPPDVTL TLQRESSV
//