ID A0A194RMH8_PAPMA Unreviewed; 790 AA.
AC A0A194RMH8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=PRKR-like endoplasmic reticulum kinase {ECO:0000256|ARBA:ARBA00041500};
GN ORFNames=RR48_07259 {ECO:0000313|EMBL:KPJ18535.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ18535.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ18535.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ18535.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ18535.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KQ459995; KPJ18535.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194RMH8; -.
DR STRING; 76193.A0A194RMH8; -.
DR InParanoid; A0A194RMH8; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProt.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:UniProt.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11042:SF91; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE; 1.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Initiation factor {ECO:0000313|EMBL:KPJ18535.1};
KW Kinase {ECO:0000313|EMBL:KPJ18535.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:KPJ18535.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000313|EMBL:KPJ18535.1};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 434..790
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 525..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 463
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 790 AA; 88900 MW; 71DF834BAAEEE012 CRC64;
MSDWYWRVIA LKAAFALTCL VSYLSADVTI QKLPFCNPHN ANGASDDAGG KWVRLVPSLR
GTLYSLSGDT IEPLPFDAEQ LLSSSFKYSD DLVIGGARET LWLGIDAHTG TVIYECGSAG
CSSEQTAGAG REVLVLRRQS STVRALEPHS GQEKWNFSVA EHQLAVSRRE CMGASAPPSP
VTVGVDMPEG VVAVRLPGSQ KPLWQQKLEA PVASMWRLQG GTLQHVDVLW QAAQALAEAE
PLPPSLYIGV HDRQLYIQES VMYAQKVETS VAAKPVPWKL KHSRPLLSKE ETALSLQDDP
DLSLVALYRN PGQTGNHGFF LYIQETCDQA VQVSDEKFEV PDVVLPNNSE NQFEHHHVHV
HVYSLWFWWK EVFLITVSTA LLLNLLIWPK LFAPKLRPPT PLPVNQEVIV VERHYERPPS
NNTKEYSGRY ENDFTPLRCL GQGGFGVVFE ARNNIDHCSY AVKRITLPKR QSKRERVLRE
VRALAKLEHE NIVRYFNAWL EEPPPEWQEK RDAILMRELG SMSVLSSEEA SSATPKSPPN
SPTNSPTNSP KADSVTLNLH KPLDHCIDAL DYDKQLREPK RHRKVTHVTG RWTCACGRWG
ARRVGGGGVG GSKMYLYIQM QLCRRDSLHD WLRHNRTWEA RRQHANVLFS QIVSAVEYVH
LAGLIHRDLK PSNIFFAPDG RVKVGDFGLV TTMGDNSQDG EPTEIDVYAR HTHRVGTHLY
MSPEQVVGRP YNYKVDIYSL GLVLFELLQP FGTEAERVHC LLRLRSGIYP DTFQHTYPAE
VRLILDAIGC
//
