ID A0A194RSR1_PAPMA Unreviewed; 1546 AA.
AC A0A194RSR1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Integrin alpha-PS2 {ECO:0000313|EMBL:KPJ19111.1};
GN ORFNames=RR48_12622 {ECO:0000313|EMBL:KPJ19111.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ19111.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ19111.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ19111.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ19111.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; KQ459984; KPJ19111.1; -; Genomic_DNA.
DR STRING; 76193.A0A194RSR1; -.
DR InParanoid; A0A194RSR1; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 2.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 2.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 2.
DR Pfam; PF20806; Integrin_A_Ig_3; 2.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 5.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1496..1520
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 179..242
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 243..301
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 305..367
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 352..503
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 504..622
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 688..830
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 837..935
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT DOMAIN 1381..1454
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 1112..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1546 AA; 166891 MW; 03D2E7A9FDA1A6BC CRC64;
MKDVVPINLT GKRACAPRYV SFVSAKLNQR NPVGSCFVAK TPDAIDVTEY SPCRNSSHGQ
RKTGVCQAGF SAALSKDGER LFMGAPGTFY WQGRTISIDT SARFDYFMPK EGQLKVQMIN
GKRSLIATQE ASSSYDDSYM GYSVTVGDFA AQGEQAVAVG VPRGADLKGL VVLYTWDLVN
IKNITGSQIG AYFGYCLATG DIDGDGTDDV IVGAPMFTKP KSSGYEHGRI YVIYQGKDRS
FVKNHARTGE VSRGRFGLAI TSLGDINYDG FGDIAVGAPY GGENGKGVVY IYHGGESGIA
EKYSQAITAE EISPSLSTFG FSLSGGVDLD DNHYTDLAVG AYKSDSVVFL KSRPVVKVMA
AVKFTGATKL ISMSEKNCRL TNGTQVSCAH LMYCLSYNGI NVDQQIDFEV TLDLDSRQKS
SKRMFVFDTR QSSYTTHILL TKGQEECREM EVYLDEDIRD KLSPIEVKMS YELVTQPSGE
VVPPVLDRTK SIVQTDSLNI QKNCGPDNIC IPDLSMAAST QQTNFVLGTG ENLNIDVKIY
NYAEDAYEAA YYLQLPAGVN YTRMERLDKE TADATTVYCT VKNRDGHNVL KCELGNPMAS
DQKSSKRMFV FDTRQSSYTT HILLTKGQEE CREMEVYLDE DIRDKLSPIE VKMSYELVTQ
PSGEVVPPVL DRTKSIVQTD SLNIQKNCGP DNICIPDLSM AASTQQTNFV LGTGENLNID
VKIYNYAEDA YEAAYYLQLP AGVNYTRMER LDKETADATT VYCTVKNRDG HNVLKCELGN
PMASDQKLNF RVVLEVDSQV NDLTFDMEVN STNPEPPESR KDNKMRLAIG VVVKADLSII
GTSDPPELHY NASLYDAINP KNDSALGPQI IYKYNIKNEG PFAVDEADIY IMWPYQTLTG
ENLMYMLVQP QSLGELVCDV ARQVNPANLQ VANPYAYMLT KEKEAMLSSG MYAAAQLSGG
SGYYGQQFWE QQTFTNENSQ SGKVSGGVSG GQVYGGQATG GHFASGGAAT GQYEGGQVYN
TQYGSGHVAS GGYGGGQASG TQYGSEQGGR QFNAGAAGNN GGTYFYNKTW TSGNDFGEDL
TAEQQEQIRK ALLAAATNPN YQGSVERKFT EGSYSQGGSV QGQSSYGQGG QVQQQGGFEG
RQQSGYSNGY ATHGFAQGGQ GQGAVENGGV YGQGGQVVRV RNKTIVYDQN HNIVSQSETS
TEYGSLGHEG EAGSSFNTYV NSQAGNQNRG SGQSFVHGSW STTETVNPDL FKAGSSKFRG
QSSVTVVGDE DEDEIGGFGA YAASNPNNEF RFGIADVSGS QGNQASGSAQ SGSRGVSNSG
YQASYGNAQN SGYQGGAGFQ GGSYQGGGAY AAGGGSSYSY SSQSGGQSGY SSHSGGSFGT
QSQRRESTRR RRQDQVDLEL KEILQKCEEK YKCEVVRCRT GRLAKGQEVW VALRSRVNAS
VLSEMSAERT VVLSTLGAAR VSRLAGGRAG GAGAWRTAEA RASLSPQLEA LPGGGVPLWL
VVLAAVLGAL LLLLLIYALY KCGFFKRNRP SDHTERQPLN GRDEHL
//
