ID A0A194UPC3_9PEZI Unreviewed; 2596 AA.
AC A0A194UPC3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Lovastatin diketide synthase LovF {ECO:0000313|EMBL:KUI53493.1};
GN ORFNames=VP1G_01033 {ECO:0000313|EMBL:KUI53493.1};
OS Valsa mali var. pyri (nom. inval.).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Valsaceae; Valsa.
OX NCBI_TaxID=694573 {ECO:0000313|EMBL:KUI53493.1, ECO:0000313|Proteomes:UP000078576};
RN [1] {ECO:0000313|Proteomes:UP000078576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SXYL134 {ECO:0000313|Proteomes:UP000078576};
RA Yin Z., Liu H., Gao X., Li Z., Song N., Ke X., Dai Q., Wu Y., Sun Y.,
RA Xu J.-R., Kang Z.K., Wang L., Huang L.;
RT "Genome Sequence of Valsa Canker Pathogens Uncovers a Specific Adaption of
RT Colonization on Woody Bark.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN714669; KUI53493.1; -; Genomic_DNA.
DR STRING; 694573.A0A194UPC3; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000078576; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000078576};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 12..452
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2596 AA; 282141 MW; 5A0786BF06BCDBC4 CRC64;
MGSQSNGVDW ANEPIAIIGM SCKFGSDATS PEKLWEMVSK GGSAWSEIPS SRFNWKGSYH
PDSERRGTTH VTGGHFMEED IGLFDAAFFN YSAETASSLD PSFRLQLESA YEALENAGLP
LHQVAGSKTS VYAGVFFHDY KDAMIRDEDN IPRLYATGTG SAMASNRISH FFDLRGPSMT
IDTGCSTTLT ALHQAVQGLR LGEADMSIVG GANVLLNPDW FKAFSSLGMV SADGRSYAFD
SRASGYGRGE GVATVVIKRL RDAIASGDVI RAVIRETMLN QDGKTETITT PSSTAQESLI
RECYNKAGLD PADTQYFEAH GTGTPAGDPI EMGAVVGAFI NDPNNARLKG NSKRKTRTEP
LRIGSVKTNL GHTETTSGLA SVIKVALALE HGVIPPTVNF EKLNPKIGHL DEKQLKVATE
LESWPVTPDA IRRASINNFG YGGSNAHIIM ENAETWLQQE GGITPGASLK ISTHDDHNDI
PQTVLENGTS NTSLSKVLVL SARDEQGCQR TVENVKLYLQ NRLDHSTATE DEELLLQRLV
YTMGERRTLF PWVAAHAIPC NQGINGVIEV LGSAAFKPLR TSRRPRIGLV FTGQGAQWYA
MGRELLGAYP AYKASINEAS GYLTELGATW SLEEELTRGA ETSRVNDVAL ATAICVAVQI
SLVHLLQTWG VRPVAVTSHS SGEIAAAYTV GALTYRSAMA VAYYRGVLVA DKSLHGPVDG
GMIALGLGIE DVQMYLDRIA ARQGEGGQVR AVAACINSPS SVTVSGDLDA INDIETMAKA
DKVFARRLRV QTAYHSHHMA PIAYPYLSAL RNTISDQEDP TSVQGGLHVA FSSPVTGGRV
VELKDISCPE YWVESLLQPV QFVDAFTDMV LGDFDPSGSS VDILIEIGPH TALGGPIQQA
LALPEFSDVK VSYYGSLVRN KNAVETMQDL SANLLKEGYP LDMGAVNFPL SKSPHISILS
DLPSYPWNHQ TRHWAEPRLN RALRERQHRP HELLGSLVLG TNPEVPSWRN ILRLSQSPWL
RDHVVQSNIL YPGAGYICLA IEGISRLVTS DRQVEPESDG GKCKTIAGYK LRNVDLHQAL
VVAESSEGTE ILTTLYTVSE KDIGSRGWKR FNVSSVTQDN KWTEHATGLI MVEYQGLDHI
SPRISAQQRE VTGYVRHVDP ADMYEGMRAA GIAHGPKFRN MKKITQSGKE MRSVSNFIVA
EKSSSDEPDG SSGLVLHPTT LDSVIQAAYT ALPGAGSVNA PPMVPKSIAE LWISGGISSQ
ASHKFTACSR LDRQDQQSFQ GDVSIVDQIC GDDIADSAAV LEMKGLICQS LGISVSPGSM
SKTWEKEICS KLEWAADLSL ASADTWDNLR KQLSYGSCEP QEAAVILELR RVCMYFVQDA
VNALTAADVA QLEKHHTAFY QWMQQQIELT AAGKMGPGSA DWLREGPLKR QLHIEKAALD
SVNGEMTCRV GPRLIDVLCH NISPLELMME EKLLYRYYQE CIKLDRSFVQ LVELFRLAVH
KSPRARILEI GAGTGGATRH MLKVLGESGA SLGEMYHFTD ISSGFFEDAR GEFAPWIDIM
AFDKLDIGQD PVEQGFILGS YDIVISCQCL HATATMSETM SNVRKLMKPG GSLLLIETTN
DQLDVQFAFG LLPGWWLGAQ DGRTSSPSLS EPLWDEVLRK TGFTGLDLGL RDCEDDGLYS
STTILSRSLP HAEASDQVTT NEVVIITDNK DSPPSDLLSL LRNSMMKATG GQGQPNVYSL
ADCSSAVMFQ GRYCVFVGEL DKPLLHNLDH DGLAALKALA TGCNGLLWVT RGGAVACEDP
NLSMAPGFLR TLRNEYVGRR YVSLDLDPSR PAWCSESIQT IVRVVKASLD LVDDTAYSAA
GAAPTEFEYA ERAGVVMIPR YYKDQSRNNY VSQETSEASV RNTSVTELLH QETRSLKLEV
GVPGQLDSLV FSDDIPTYDE DELADDCLEI EPRAYGVNFR DVMLAMGQLH GHTDILGIEC
AGIVRRVGRD AGAHGFKVGD RVFCMRQGFC KSRLRVEWLL AAHIPPNFTF EDAAALPVVF
GTAYIGLYDV AGLQAGQSVL IHAASGGVGQ AAIMLAQRVG ADVFVTAGTA EKRQYLMDKY
GIPANRVYHS RDASFGTGIL RATSGRGVDV VLNSLAGPLL QESFRVLAPY GHFIEIGKRD
ILSNNHLEMG SFIHNTTFAA VDLHAMLCDR HQYVHRIMTG IERLAELGSI SAPKPVTVFP
MADASTALRH LQTGKHMGKA VVSAGPREMV PVVPQARIVK FPANESYLLV GGVGGIGRSV
AHWMVAHGAK NLILLSRSAA SSEKTGAFIS ELQEAGCRVI AVSCDVADEA GLAEALCASE
RELPPIRGII HGGMVLQDSI LEQMTLDDYT TAFRPKVKGS WNLHNEFTRR GRHLDFFIML
SSLAGIIGHA SQSNYSASGA YQDALARYRV GQNLPGVSID VGIVKSVGYV AERADVAERM
ARLGYMPISE DQVLRVLESA ILEPCSPQVL VGLQTGPGRV WEPNGESQLG RDSRFAALRH
CQTMKIQQKT SSGARSDREV LTLSDKLAEA TSRDDAETLV SQAIAEKLST IFMIPIGEID
PTTKLSHYGV DSLVAQ
//