ID   A0A194UV77_9PEZI        Unreviewed;       500 AA.
AC   A0A194UV77;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Steroid 5-alpha reductase C-terminal domain-containing protein {ECO:0000259|PROSITE:PS50244};
GN   ORFNames=VP1G_02931 {ECO:0000313|EMBL:KUI55568.1};
OS   Valsa mali var. pyri (nom. inval.).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Diaporthales; Valsaceae; Valsa.
OX   NCBI_TaxID=694573 {ECO:0000313|EMBL:KUI55568.1, ECO:0000313|Proteomes:UP000078576};
RN   [1] {ECO:0000313|Proteomes:UP000078576}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SXYL134 {ECO:0000313|Proteomes:UP000078576};
RA   Yin Z., Liu H., Gao X., Li Z., Song N., Ke X., Dai Q., Wu Y., Sun Y.,
RA   Xu J.-R., Kang Z.K., Wang L., Huang L.;
RT   "Genome Sequence of Valsa Canker Pathogens Uncovers a Specific Adaption of
RT   Colonization on Woody Bark.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KN714681; KUI55568.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194UV77; -.
DR   OrthoDB; 38588at2759; -.
DR   Proteomes; UP000078576; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1630; -; 1.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR010721; UstE-like.
DR   PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR   PANTHER; PTHR32251:SF15; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295); 1.
DR   Pfam; PF06966; DUF1295; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078576};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          348..407
FT                   /note="Steroid 5-alpha reductase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50244"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  54373 MW;  0555F032D3FE1077 CRC64;
     MAEQDTYGSH WGAKPTNPTT GSVPIPVPRG SGAEQDRFGS HWGSNANNPT RGDIPVPVPT
     ASGAEQDRWA AHLSWSATRN PEAEGVSFRV PTASGAEQDR YEAHWSRAGP RNPEAEGANF
     KVWSGSGSEQ DRYASHWSRA EANNPTSDRI GIPVRGPSSG YSEQDVYGGH FTGDKYNIPR
     NATAVGILQD TLLPSLGFHS GLAITAYAAS RVANRVDGKD WLWPAGQVAN AWWSAVGTRV
     VYDGVSLGTA LSSLVYPDKV LLGGVTAWGA RLFYQVVSRS VESKSDDPRY LAQKQEPGFW
     NKAFFSMFLP EAVIQAVISL PFTLPFRNPY ASARSSLSAP VEWAHDLAIF IFSAGFALEI
     LADYQLNSHK KKTANATLNR EGVWSIVRHP NYLGDALVHL SFPLFLWGSG KLHPITLLGP
     AANYAFLRYV GGDAQNEAYQ EKEYAKNPVK ASDFAAYKHS KNSFWPKVQE GANPWTLAVL
     GAGAAGLVVE RVVRHFALQS
//