ID A0A194YRE5_SORBI Unreviewed; 672 AA.
AC A0A194YRE5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=SORBI_3004G246100 {ECO:0000313|EMBL:KXG30803.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG30803.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:KXG30803.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CM000763; KXG30803.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194YRE5; -.
DR STRING; 4558.A0A194YRE5; -.
DR EnsemblPlants; KXG30803; KXG30803; SORBI_3004G246100.
DR Gramene; KXG30803; KXG30803; SORBI_3004G246100.
DR eggNOG; KOG2657; Eukaryota.
DR InParanoid; A0A194YRE5; -.
DR OMA; ECVYPGV; -.
DR Proteomes; UP000000768; Chromosome 4.
DR GO; GO:0005798; C:Golgi-associated vesicle; IEA:EnsemblPlants.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..672
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008269036"
FT TRANSMEM 641..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..207
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 672 AA; 72080 MW; 9897104CCB6553A3 CRC64;
MAAGSAASLV AAAICLALAV LAPAVPGGGA TLESVPDLVK AMYLNIESSP CVRLLNLSGE
IGCSNPGSEK VIAPIVRFRK SSDQLIQPST ILLPLDQMSD FFLRVSNDPE LYQKVAGVLI
ESNGVNGDLQ ELSPDRKFPQ DDFAPYSNHS HDWNLAGSGI MWNRYNFPVF LLSEESTKTL
QKISEKNEKT SNGYRANVAE FDLVMQTTKA QTHDSASCLK EQSCLPLGGH SVWASLPPLK
NGSTEHQKPL ILAIASQDSA SFFRDRSLGS DSPISGLIAL LTAVDALSHI HDLSNLKKQL
VFAVFNGEAW GYLGSRKFLQ ELDEGAASVN GISSLMIDQV LEIGSVGKAI LEEYPSFYVH
AEGNSSTSKT ILDALQSASK SLGSDNVKVK QAASSNPGVP PSSLMSFIRK NTSTSGVVLE
DFDSHFSNRF YHSYLDNPVN INSSSIAAAA ALVARSLYIL ANDGSVVDLI TLNTIKVNVS
LVEELIGCLL TCNPGLSCGL AKRFISPSNS CPSHYVGVFL DDPSGTQFPS YADDTSRFVW
NFLADRTSNL AGNKSSCTGK CADEGEVCVG AEVEGGGRCV VSTTRYVPAY STRVKFENNA
WHILPANSSD PMGAADPVWT ESYWNTIGLR VYAVQDSAYD WLILLAGLII TAASYCAVQF
GTTYISKVVK HD
//
