ID   A0A195AUY9_9HYME        Unreviewed;      1273 AA.
AC   A0A195AUY9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=DNA topoisomerase 2-binding protein 1-A {ECO:0000313|EMBL:KYM76058.1};
GN   ORFNames=ALC53_13543 {ECO:0000313|EMBL:KYM76058.1};
OS   Atta colombica.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Atta.
OX   NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM76058.1, ECO:0000313|Proteomes:UP000078540};
RN   [1] {ECO:0000313|EMBL:KYM76058.1, ECO:0000313|Proteomes:UP000078540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM76058.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KYM76058.1};
RA   Nygaard S., Hu H., Boomsma J., Zhang G.;
RT   "Atta colombica WGS genome.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KQ976736; KYM76058.1; -; Genomic_DNA.
DR   RefSeq; XP_018057274.1; XM_018201785.1.
DR   AlphaFoldDB; A0A195AUY9; -.
DR   STRING; 520822.A0A195AUY9; -.
DR   GeneID; 108693088; -.
DR   OrthoDB; 449768at2759; -.
DR   Proteomes; UP000078540; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR   CDD; cd18434; BRCT_TopBP1_rpt5; 1.
DR   CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR   CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 8.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR049542; TopBP1-like_BRCT0.
DR   PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR   PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR   Pfam; PF00533; BRCT; 2.
DR   Pfam; PF12738; PTCB-BRCT; 2.
DR   Pfam; PF21298; TopBP1_BRCT0; 1.
DR   SMART; SM00292; BRCT; 6.
DR   SUPFAM; SSF52113; BRCT domain; 5.
DR   PROSITE; PS50172; BRCT; 6.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:KYM76058.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078540}.
FT   DOMAIN          131..179
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          207..292
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          368..460
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          577..660
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          666..763
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          1047..1129
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   REGION          830..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        890..927
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1273 AA;  144065 MW;  F4AFA39246AE4DBE CRC64;
     MTTQESTIEC DVNIYFVIPS HLKSEDDCSE NMWQTFDKCN KLSLHPVWIS EQVCYNMEPQ
     KNDVFVIEEF KGEVFEKLKN FKCSIVSPKC LLICFLNGES IPEGKSPIYT TSMRKMCICA
     SGFDAEIKDW IQQRVEYMGG IFTKQLRSSV THLVADNVMS AKYEKAIEMK IPVMTKEWIE
     AVWKENLKEV IKADDKIFDR YKCPVFMNLI VTSTNIQRRQ KEEIKCLIQQ HGGIFMGPLD
     GTKVRVVLTT EIGPLSDKLK YAMENDIACL KLDWVYESIK IGYALPFPNF IIQSVKACST
     PEKSNTQELL NCSNISSIAH DKRHTNMISE SFCTTISNYS NIDAVIGKPS STSKLNVLDR
     LTFGEAKSVG PFLDGCNIYL AGFVTSVRDK LNKILNVSGA TRFDDISGAV THVIVGDESK
     ASAELKTIKS EGLCPYILNV EWLEESMKLK RPASEELFLF EVKDVVSKKN IETPASPLSK
     KNLQMLQQSK RSLPSLNLEK VLPLVNEDEQ PDLVQQYLQE NDDSSIRHEF IKPFTPVSKN
     KDRGSLSKAK SAHTSVLDMT KNVESDNTMP LSQSYMVNEK LFKGLTFVVA GFDDEDNHIE
     TIVMLGGRLA SRTYSGIPDY GIVPVYGAPL KYTVNEIVND LFIDDCVNQE EIVDIMYYHR
     PLSIRKPCNP LSGCVITMSM YTGSERMYLS TLAMKLGAIC QDMFARKANA EKNTHGSTHL
     VCPSPEGNKY NAAVRWKLPA VTADWLKTCA DELTLVDETP FLVGETIAPV RTTSEANLSV
     TGENRLNPAE EITSRMITPI LHLSQDALSA ETPLINKRLN FVMNQTSPSP FHVSTPESPY
     GQVFKPNPSP DTRKGWIKWT ENFPDLQVEE PPLKRRARST PLSALKRQLW EKLKNPDQSE
     KEHKLNQTMR HDDDNDSFSK RAEEESNKTV STFVPPINRK LDFDEKSSPI SKEINMQIAQ
     LDQMLQRTSS TPENRYSLSD ENAKKYNEAS DHIQKCIVKD SQAIDAIVWE DPDHPKRSTL
     GKRSSNDNSN VIHKEHEDAI EYELSTTRKF MLSGIKDRIA YEQVIRDLGG DVSTDANFDS
     SATHLLCMRL SRNEKMLSSI ASGKWILHCS YLQDSKREGR FLDEEEYEWG NSKSKNKIPE
     PSSKLENAIG AAVYKWRLKL QKESYGPFSN MVALLMVSEE KYDQFKRLIE AGDGLVMQAK
     PPYDASPSGR RITHCFVNVK QVNQSVDWAM LASKGILCFL PQYLSDYLTA VTPLNPRDCV
     LPEFKKYLAL LPK
//