ID A0A195B0Z9_9HYME Unreviewed; 295 AA.
AC A0A195B0Z9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Ubiquitin-conjugating enzyme E2 C {ECO:0000256|ARBA:ARBA00039887};
DE EC=2.3.2.23 {ECO:0000256|ARBA:ARBA00012486};
DE EC=2.3.2.24 {ECO:0000256|ARBA:ARBA00039076};
DE AltName: Full=(E3-independent) E2 ubiquitin-conjugating enzyme C {ECO:0000256|ARBA:ARBA00042725};
DE AltName: Full=E2 ubiquitin-conjugating enzyme C {ECO:0000256|ARBA:ARBA00041791};
DE AltName: Full=Ubiquitin carrier protein C {ECO:0000256|ARBA:ARBA00042389};
DE AltName: Full=Ubiquitin-protein ligase C {ECO:0000256|ARBA:ARBA00042312};
GN ORFNames=ALC53_11353 {ECO:0000313|EMBL:KYM78158.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM78158.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM78158.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM78158.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM78158.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-
CC cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.24; Evidence={ECO:0000256|ARBA:ARBA00035845};
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC {ECO:0000256|RuleBase:RU362109}.
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DR EMBL; KQ976681; KYM78158.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195B0Z9; -.
DR STRING; 520822.A0A195B0Z9; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR CDD; cd00195; UBCc; 1.
DR Gene3D; 1.10.10.1450; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR041426; Mos1_HTH.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR023313; UBQ-conjugating_AS.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR24067; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR PANTHER; PTHR24067:SF338; UBIQUITIN-CONJUGATING ENZYME E2C; 1.
DR Pfam; PF17906; HTH_48; 1.
DR Pfam; PF00179; UQ_con; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS00183; UBC_1; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362109};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362109};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU362109}.
FT DOMAIN 134..284
FT /note="UBC core"
FT /evidence="ECO:0000259|PROSITE:PS50127"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 223
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
SQ SEQUENCE 295 AA; 34500 MW; 58098AD4EE206C82 CRC64;
MRDARTAVSG QLRSHRSPEN RKDDARQPAS QPVAEECFHL KNTVAESYRL FGEAYGEHAP
AQKTCERWFQ RFKIRDFDVA DKEHGEMERR KNTCEILLER YRRKSFLHRI VTGDEKKKSW
IDPSAPSTST ARWNQKDVVY YELLKPYQKR KHKVISLHDN APLHMAKPVR DTLEALSWEV
LVYAGLTYKL TLEFPHSYPY SAPIVRFATP CFHPNVDTGG NICLDILKDK WSALYDVRTI
LLSIQSLLGE PNNESPLNLE AAELWNNQTK YKKYLMEEYH RALDRTQSNR NQQDS
//
