ID A0A195BLI8_9HYME Unreviewed; 568 AA.
AC A0A195BLI8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
GN ORFNames=ALC53_04448 {ECO:0000313|EMBL:KYM85667.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM85667.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM85667.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM85667.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM85667.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ976450; KYM85667.1; -; Genomic_DNA.
DR RefSeq; XP_018045522.1; XM_018190033.1.
DR AlphaFoldDB; A0A195BLI8; -.
DR STRING; 520822.A0A195BLI8; -.
DR GeneID; 108685308; -.
DR OrthoDB; 5403423at2759; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540}.
FT DOMAIN 413..558
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 123..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 64810 MW; 070852BB74C1EB95 CRC64;
MTSMLSGEES NSVRMKQKLM RNAPAKEETR SFLNFSRENL SISHSDLEQG FNRSRLIRPS
RNTILSVAAL IVAVLCLGLQ SWKLLSNTHE IEQLRKDVDI LKHRFLEQDL MDELKAFEEQ
LYAEESTEDN DPGEADIDNA DYDSNYDDDG SASHDYSGDY HTPLTYGARP SDFLDITSTS
IPIPTSPDPG ANEDMVELLT ALHKVEAKHG QDFERDIREN HKTIERERLK GGHKGQLNHE
KKTKDVNSTR HKPDVLTRGA TNLEYIKEDI KSKRSVNDGS SDDFVRDETN GKRHNTRRIV
SRARSYANGE NNTNDNSGTN STLHPPKKYH VNALETIPSA HHDHLSEGIT QPDRYESENT
ETVSDRRISW RNRDTSRNKT EIRQAVQNHE VAARENHRTL TRRHLRAPRQ VYAIHYGADS
TLFSTQDEHT GNGRVRHYDG VFRAWKPSEW VADLGMSRHF TLAGDGKLSV HESGLYLVYA
QIHYLDRHDE NGFRILVNGR SILQCMVYSP GMDHKSRSCF SAQVIVLQAG DHLVLKDIGA
ARFTLFHHDK SFFGLVKVGE SRQQQRHP
//
