ID A0A195BPK7_9HYME Unreviewed; 1063 AA.
AC A0A195BPK7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=tubulin-glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00026108};
DE EC=3.4.17.24 {ECO:0000256|ARBA:ARBA00026108};
GN ORFNames=ALC53_02935 {ECO:0000313|EMBL:KYM88452.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM88452.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM88452.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM88452.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM88452.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] +
CC H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-
CC glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA-
CC COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555,
CC ChEBI:CHEBI:149556; EC=3.4.17.24;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; KQ976424; KYM88452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195BPK7; -.
DR STRING; 520822.A0A195BPK7; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.60.40.3120; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040626; Pepdidase_M14_N.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR12756; CYTOSOLIC CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR12756:SF11; CYTOSOLIC CARBOXYPEPTIDASE 1; 1.
DR Pfam; PF18027; Pepdidase_M14_N; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|EMBL:KYM88452.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000313|EMBL:KYM88452.1};
KW Protease {ECO:0000313|EMBL:KYM88452.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540}.
FT DOMAIN 635..762
FT /note="Cytosolic carboxypeptidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18027"
FT DOMAIN 792..894
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|Pfam:PF00246"
SQ SEQUENCE 1063 AA; 120962 MW; 31B7A81F9937D316 CRC64;
MSANNKNADE VVSDALLEKL RTYAAKPQEA GDALRTIVAK IHMRITSSDR RIRERTLEKL
WLKNSGAMES FIMTLENCKD YVANCSIAGI LHECISPRMI KGKSKERGSK NRSATRTSNR
MAVIQLINLG ITQVLVKLLI NLQYADSIMI EVLTQDILWI LGQVAQRDQK FVSKMKLLNS
IKVFHALLKQ HYNNSKTLLP LLLIIKTLAK NSFSLQTLVK DDITSTLEKT FISVGYTPHL
KLRTLLECFK HLTTNKLCCN KFIKTRIVHL LMRIFERWER FDGQMRLKIC NYALNTLQHF
CVIKAGRKAI KSNNGLQLLY RFCTSCPEDK AYDCLLSRIY GIINQCLDKK ELPVPEMSPA
RFILSEVNVR ANSAESGSDI DSQANSVASI GRRYSDLDSG DDEESHDSRD TMDNEIHLGD
EVDENKFFAG VFTSQRSEED LAGYHMFFKE LGNLQSQLHI VGSTNGKLID LYLMDAEQIN
SPLAKAGKTK ISIKDFSKSN GTMKSCQLVN STHNLKILKD VSANVTDRQA YCVVASRVRS
VIGFVKVAYP DLIGGDGLGK AEPLNTKDRK VCRAKLLTCV ERGLHAATTF QEVVYDLDAL
ANSVSRGTSD DEWLFDNRDE KRIGKRNVDM KRLQFESRFE SGNLRKAIQI GPREYDLILT
PDVNSGSRHQ WFYFEVSNME ATAYTFNIIN CEKTNSQFNF GMKPILFSVT EAQCGRPGWV
RTGVDICYYR NCYQRSIKGK TYFTTSFTVM FPHAYDVCYL AYHFPYTYSR LMTNIWNWTK
SVSVANVYFR AETLCETLND NENPVLTITS PDSKTNPIHT RKMIFLTSRV HPGESNASWV
MHGTMEALLS DNQYANSLRD DYVFKIIPML NIEGVVNGCN RYGLTNEDLN RRWSNPNRMY
HPVIYHTKGL MEYCARVLQR PPHVFVDYHG HSRRKNVFLF GCSRSGSWSA ADRAKPDQSV
QYLMLPHLMQ RTSSAFALPL CSFKVERNKE STARVAVWRQ LGVPRSYTME SSFCGCDQGV
LAGLHLDTEH LKAIGRDFCQ ALSMMKDGGS DWAIGKYVQI FCY
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