ID A0A195BRJ0_9HYME Unreviewed; 5020 AA.
AC A0A195BRJ0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Cadherin-related tumor suppressor {ECO:0000313|EMBL:KYM88569.1};
GN ORFNames=ALC53_03052 {ECO:0000313|EMBL:KYM88569.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM88569.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM88569.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM88569.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM88569.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ976424; KYM88569.1; -; Genomic_DNA.
DR STRING; 520822.A0A195BRJ0; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0001736; P:establishment of planar polarity; IEA:UniProt.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR PANTHER; PTHR24026:SF125; FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG; 1.
DR Pfam; PF00028; Cadherin; 32.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 34.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 13.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4476..4499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..98
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 99..211
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 212..326
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 332..438
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 439..543
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 544..651
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 652..862
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 872..967
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 968..1071
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1072..1180
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1181..1286
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1287..1391
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1392..1502
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1528..1626
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1628..1738
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1739..1852
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1853..1958
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1959..2065
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2065..2168
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2169..2277
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2278..2383
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2384..2488
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2489..2590
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2592..2696
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2697..2800
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2800..2900
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2901..3011
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3012..3119
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3120..3224
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3225..3335
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3331..3436
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3437..3542
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3543..3650
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3829..3887
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3889..3925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3928..3966
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3968..4004
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4005..4198
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4278..4459
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1776..1805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4590..4624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4652..4702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4741..4920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1780..1797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4595..4609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4741..4794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4807..4823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4883..4897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4898..4912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3877..3886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3915..3924
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3937..3954
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3956..3965
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3994..4003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 5020 AA; 552197 MW; 429B97F512AE362F CRC64;
MQSRAVDTRV QLEIREGEPK GTIVGTIPVK PDFTYRFNEP PQEFILDPET GKIRTAMILD
REALSSDRFD LVVLSSQPTY PIEVRILVLD INDNNPEFPE PSIAVSFSES AVAGTKLLLD
AATDRDTPEN GVLDDYFIVD GNTDNKFRLE VTGNPGETSY LHLETTGKLD REQVEFYSLN
ICARDRGRPP RLGYLLVNVT VLDVNDNPPV FSQSDYVVAL NESAPVGTKV LTVHATDKDS
EDNSKLTYYL PDNERKFTID PETGMITTAE PLKCPQQRCT VARPGGGCPK SCVITVFARD
HGAPKQDGRT YVTVNLLDAN DHDPVIKFSY FPQNAGFATV DENTAKDSIV AAVAVIDDDE
GLNGETSVEI RAGNELGHFR LEVTESFDIV RVDGRLDREE IPKYNLTVVA TDKGTPPRSA
TAYLVIHVND VNDHEPVFQQ SEYSAVLSEF APIGSFVASI SATDADSGLN ARIYYEFGSG
NEQSWFAIDS DTGLVTTVAS LDREVQGSIE LHVSARDGGP NTKYASTHLK ITILDENDEV
PRFPEDIIEI ALSENTAPYS LIATLTAVDN DQGTNGSVAY SFHSSVLRDY SKTFALDALT
GQLTTITALD RETIAEYRLL VIAKDQGTPV QSSTATVVLT LQDVNDNSPI FYPWKYLMSI
SEDISAGTTI GKVTATDADA RENAQVKYTL ESGGEGLFVV EERTGEIVLQ GSLRAAHKTL
YELIISAKDI DNQVAARNAV VEIIREEDLE HLEFDTYNGY EFRVLEDHGD CDYVTSGNRE
IGSVHVTQYG NTGKVSYAIV FGDPKGNFRI DENTGVISTT GCLDRERVAY YSLQLSARTN
LAYGQTIVNI TVQDVNDNPP RFPRGEWGDE ILQENAAVGQ EVCLARARDR DIGTNSRIVY
SLTHNPDGQF RVAENSGIIY LNKPIRAPPG TILQLEVTAT DSGRQPLSAQ YQVRVTIEDV
NDHTPIFRLN SYETSLSEST PVNERFFSLT AQDADLGNNG RILYRITDGN AESRFGIFPD
GQLYVKNELD REERDYYALE ITASDQGSPS RSSMVPVVVH VIDENDNAPE FTNSSFSFHL
RENEPPDTFV GKLLATDRDV GHNADLIFLL PLIQNDFVID PRNGFIRSEH VFDRELLVTN
TGSNYINLEA TVIDNGINRL RDRVKVTIYI TDINDNVPQF QRLPYRVQVS EGAAIGTQLL
RVYTTDADEG LNGDVFYSLE DGNQHGHFMI DEATGQISLM KELDREMSDT YVLTVVAHDA
GLETRLSSSA TVYIEVLDEN DNVPFFVDNK SRISVLETMP INTELLRFKA TDNDLGPNSE
LTFAISAGNK RDTFYIDPLT GILYLRKSLD YEEQIRYTLN ITCSDGGHPR LSSVTSVTIE
VIDTNDNPPV FPNTAIVRQI REGILVRTPI VTITAEDPDS GDNGVVSYSI LSQEPQDQVR
RFSINPSSGV IHTLLPIDRE EVDTFNLVVV ATDQAHPPSA RLSAEKQVIV FVEDINDNAP
IFVSMSAIVL PPLSAGNFNY HQTENIQVMQ LLARDLDSST NGLVTYELLR SSVNYSNMFE
VYRNTGELIM KLPQSFSKGS LFKRASFKYQ VGVRATDEAV QAERRSSETY VTLIVPGEDG
DDQPIWEHQG QIEGNVYENE PIGTSILRVS ACSRQSNIEL EYYVTNVTAG DGPQVDRLFD
IDTKTGVLST AAQLDRETGV QWYEVELYAI GIGGTKPSTT STKVRVTVLD KNDVAPTWGP
GPWKFNISEE APPNTVITVL EAHDPDTIGT LTYTLVPNHH RPGDRGESAD DDETQGQFKL
HPTTGQLSLA ESLDRETKER YVLKVRADDG LQHRDIVLHI QVTDTNDNAP TFQSTAYSFD
VPENVPRGSR VGQVVATDAD AEGSNSHLSY VLISDWANDV FSLNPSTGVF TLTASLDYEQ
IQHYIFVVEA TDGGVPVLSS TVTVYCNVVD LNDNSPIFEA GPHAVDIVEN ATIGTPVLTV
TAQDLDSGDN SRVVYTVASG DEDGDFGMAH NGTLFIRRAL DRERKQIYNL VLSATDSPLP
PARPLSSTVQ VTVVLLDVND MSPEFISSRD ITISENAAIN TVVMTIKATD RDEGRNGYVE
YTLKDDNNLP FILGLSDGSL RVSGSLDREQ RSNYTLEIIA KDRGDQPRSS STTVSIMVLD
ENDNSPVFDP KQYFATIAEN ASIGASVLQV SAMDRDEGAN GRVRYSIAMG DDNRDFTISE
DGGVIRVAKN LNFERKSRYH LMIRSEDCAE EVGKEPRSDT AQITITVLDI NDNAPIFLDS
PYLAHVMENM VPSSGFVIQV KAYDADTPPY NDQVRYFLKE GDTDLFRINA STGDISLLRP
LDRELVSEYT LTVSAMDTGS PPLTGSGIVK IVVLDVNDHS PEFARQDYKA TVIENAPAGT
WVIKPHATDK DEGFNAKISY NLLGDKAERF SADPDTGEVF TTVPLDREQT AVYYLTLVAR
DSSPTEPRAS AVNLTIYVTD VNDNAPRFSS PRYTAYVPNA TKSGDFVFGA KANDDDDGEN
SRIVYRLHGK DANRFTIDLN NGVIRATQEL IDDQTTYQLQ ILASDCGVEP QHVTADLVIH
LWERQLFPSF RSSVTTRFTL SEDVSESKVI TKLSATTPKS GPASNLIYGI AGGNVGDALR
IDPHTGEVVV ASGFDYETAP HYEAWIEVRD SDTPPLRSVL QLLVNVTDAN DNAPIMEAAI
YNATVIEEEY PPLFIIEVSA KDRDSGENGQ VTYHLVDDFS GFFIIDSRTG QIETNEKLDR
EEIASYELIV EVRDQGHPQL TGTAMVLVTV LDKNDNPPHF TRLFSVNVTE NAEIGTFVIR
ITSSDPDIGQ NANVSYSFTE NPGMKFSIDA LSGNVTVAGQ LDREEQDEYL LKVAAGDGAW
RAETALTITI QDQNDNAPEF DGDTYHFLFP ELQPQVMHVG TVAATDRDKQ GPNSVISYSL
LQPSDLFTVD PATGDVFSKR ALRYKHTHRP SSPENLYSLT VIATDNGKPP MSSKAVVHVS
VVDANNNAPR FEQRSYLSAV PENCEVGKRI IQLIAHDDVD FGVNAEVSYS LENMNETDVL
FAIEEQSGWV YVRKSLNGIP IGATFLLKAR VTDKGVPPQK DEIVLTLIIS GENKHTPAFV
ADNYQVRVPE SEVINATLQT VYAYDNDSGP NGMIRYTISS GNEKNQFYVH PVTGVVTRLE
PFDYDQVQEY RLNITATDMG FEPKQVVAIL TIHVTDINDN PPTFNQSIYE AFLPENSPPD
SFVYKVVARD IDSPKYAIVQ YEILGGTGKD YFRIRGNTGV ITSDATFDYE ETNEYTLDIV
AANPDSNPQM VGFTTVVVHI TGVNEYYPHF IQPVFHMDVS ESAEVGTSVG AVQATDQDSG
EDGRVYYLFV GSSNDRGFSI GSDTGIVRVS RQLDRETQNR VVLTVMAKNS GGIRGNDTDE
AQVIISIQDG NDPPEFLQNN YDINVSESAT HGTRVIIVRA IDKDIKPQNN QFSYSIISGN
LGQAFKVDPQ TGDIETAKQL DRETVPSYDL TIGAIDTGSP PQTGTAMVHI ELQDVNDNGP
VFDPPEVIGY VSENEPAGTS IMTLSATDPD LPPNGAPFTY RLIGGRQSEM VTLDKHSGIL
RTTRRLDRET MPQLELMIEV EDSGIPRMKS EHNIIVIVTD QNDSPSTPRS VHVMVHSFNG
KTPLGKIADV HPNDPDITGT FTCKIIQGAS SRVLTIPTAC DLHTNKITAG TISGNDGRHP
DVVSKVTVDF LIFSNSTIEN SVTLQIFKLT ANDFLSRYYR ALLDLLQQKI NVGETLTIFS
IGENGPDLNV HLAVESPQGY RMRYEVTELL MTNQAQIQTL LEDHSFFINY SPCKHMPCEN
GGSCSDRLAI YDDARITDSQ ALILTSPRML HEMACKCRDG FTGDRCERRQ DPCSPNPCLL
GGQCRRLGYD FQCTCPIDRD GKLCELERGD ACASNPCRNG GSCRKSPDSF SFFCLCRAGY
RGNHCEAITD SCRPNPCLYG GLCVGEKPGY RCSCPEGRYG RHCERSTFGF HELSYMAFPA
LDSNTNDITM VFATTKPDAL LLYNYAPQTG GRSDFVVLEL INGRVVFSYG GARSAITTVT
IKTDRPVSDG EWHKVTATRN GRVISLSVST CKEHGDVCDD CRPGDGTCYA GDVGPTGTLN
FNNNPLLLGG LENADPVLER PGQVHSDDFV GCIHSVSING RTLNLTNPLA SRGVKSTCVR
SQRNPCLKDE KDAASVCDVD AQCHDKWHQV MCQCGSLRAP NCHGALEPIT LSEGGFIQFK
ISEKHRRMQL LEYLYGGSTI WHMNRVKRGL IEDTSFITNP SLKTISLMFK TVRPDGILIY
AATNKHFTSV ELRNGQLIYM SLLGSPVNMS INIEGSLADG RWHNLTLHAY ARGLRLLIDN
TLTGDELDLA GVHDFLDPYL SVLSIGGVSQ DLYYAHNAGF KSFEGCLANF TINNEVQPFN
GSGSIFKNVL YHGKVNTGCR GPIGIGAATA ADPLSIGITL VIVFFVILLI AILVSFIVFR
LRRQNKEKSA PSVVNKNTNA IMTGNPLVGS GNDNLMSRHE NTYISDTSDL RGVGHMGPEL
ISKKYKEREI NSTAEHRPQR PDIIEREVTK SPPIRDEHPP LPPPTQISLH PHEHNPEPDI
PEHYDLENAS SIAPSDIDIV YHYKGYRDGM RKYKATPPPI GNYGNHHKHT GQQHRHNGPF
PPRAMPPPNV NQSSGPAPKL LQSTPLARLS PSSELSAQQP RILTLHDISG KPLQSALLAT
TSSSGGVGKD ALNSNSERSL NSPIMSQLSG STASRKAPQS NNENSVNNVS SGPMGLTAEE
IERLNSRPRT SSLVSTLDAV SSSSEARGPP AHGPLHHHRR HTPPVERLER RNSSTTDESG
NDSFTCSEIE YDNGSLVGDK RSDNLFAKQD DERSSPQGRS NVESSQSKPP LPPNVGNYDG
FDSSFRGSLS TLVASDDDLS THMGGLLYGT HATNGSPTTT TTTTTTAAAE DALSWDYLLN
WGPNFESLVG VFIDIAELPD STSRVPRLPA NIPKPSEEYV
//
