ID A0A195BWD0_9HYME Unreviewed; 381 AA.
AC A0A195BWD0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN ORFNames=ALC53_01046 {ECO:0000313|EMBL:KYM92590.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM92590.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM92590.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM92590.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM92590.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR EMBL; KQ976401; KYM92590.1; -; Genomic_DNA.
DR RefSeq; XP_018054287.1; XM_018198798.1.
DR RefSeq; XP_018054294.1; XM_018198805.1.
DR RefSeq; XP_018054300.1; XM_018198811.1.
DR RefSeq; XP_018054309.1; XM_018198820.1.
DR AlphaFoldDB; A0A195BWD0; -.
DR STRING; 520822.A0A195BWD0; -.
DR GeneID; 108691139; -.
DR OrthoDB; 5391764at2759; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788:SF10; PROTEIN-TYROSINE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000078540};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ SEQUENCE 381 AA; 42995 MW; E25756AD89D8B074 CRC64;
MFLSSRSGRK GPIACLVGLL LIFALYQLGI ICGSTRYMPT AMMVSKEKYV IGPFDRKTYT
YDRYMPLIFI GGVPRSGTTL MRAMLDAHPD VRCGQETRVI PRILQMKMHW SKSEKENVRL
TEAGISKEVI DSAIAAFCLE IIARHAEPAP RLCNKDPLTL KMGSYILELF PNAKFIFMVR
DGRATVHSII SRKVTITGFD LTSYRQSLIR WNHAISVMYG QCKELGPERC LMVPYEQLVL
HPRQWMKKIL NYLDVPWNES VMHHEEFINK PGGVPLSKVE RSSDQIIKPV NLAALTKWVG
NIPEDVVREM ADVAPMLSVL GYDPYANPPV YGAPDSLVSD NTRRVLAGEK LWEEKARAYH
LSHRPIENSN EEAASSTAPV A
//
