ID A0A195BXG7_9HYME Unreviewed; 652 AA.
AC A0A195BXG7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE RecName: Full=Frizzled-4 {ECO:0000256|ARBA:ARBA00018149};
GN ORFNames=ALC53_01101 {ECO:0000313|EMBL:KYM92643.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM92643.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM92643.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM92643.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM92643.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; KQ976401; KYM92643.1; -; Genomic_DNA.
DR RefSeq; XP_018051825.1; XM_018196336.1.
DR AlphaFoldDB; A0A195BXG7; -.
DR STRING; 520822.A0A195BXG7; -.
DR GeneID; 108689539; -.
DR OrthoDB; 3058928at2759; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07448; CRD_FZ4; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041765; FZ4_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF99; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 2.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..652
FT /note="Frizzled-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008269733"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..138
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 196..509
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 626..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..645
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 22..83
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 30..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 67..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 94..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 98..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 652 AA; 72028 MW; AFA9202051E29F6A CRC64;
MRWILLPLLT LIRAIWCAHG ACEPIRIEMC RGLGYNVTVM PNLVGHEIQG DADFTLQTFS
PLIQYGCSAQ LHLFLCSVYA PMCTEKVPAP IGPCRGLCEQ VRARCYPVLQ GFGFPWPAAL
NCSKFPPENN HQHMCMEGPG EPGPANPIQA ISTSNGPWGC SWYAKSGLYI FLNRSGRCAA
ACDADILWSQ KDKRLAEAWM AVFVTVSLVS VAIAILTLLK PRKRPILTSP AERAIVFLTI
CHAAVAIGYV IRLAAGRLNV ACTPVIQLHP QEQAVLAQQQ QQLQQQQQQY LTQDGLANPY
CAVVFLLLYY FGNAAIVWWV VICAWWCIMA RKWTRTAGNY KEDSFGLQQG FSTVATVAAW
SLPAAHTIAV LVTRDVDADE LTASCFVGQQ NAHSLLVLVL APQFVYLSFG ATFLLIGLAT
LALPRRPTVT PTSTSMSTTS SSSSTTAAAA AAAVLTALTA SHANPLRSQR SEISGKLSPG
EIHRRQKQLL TRVGIFGCLY AILIICLAST TFYEWWGRET WLRAPEPSTA PRIPARPLLQ
VFILRLVVTL GAGVMAAAWI WWPEITNTCR KLPHCKQPPH KCHPIPLVHT CQYNAANPIP
HQIHHLAHLT PPQHPLLQHA TLTNSQLPHR NHKNKKHRKH RKHYHSGSET QV
//
