ID A0A195C3C5_9HYME Unreviewed; 518 AA.
AC A0A195C3C5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neural Wiskott-Aldrich syndrome protein {ECO:0000313|EMBL:KYM94691.1};
GN ORFNames=ALC62_14672 {ECO:0000313|EMBL:KYM94691.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYM94691.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYM94691.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYM94691.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM94691.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KQ978350; KYM94691.1; -; Genomic_DNA.
DR RefSeq; XP_018404486.1; XM_018548984.1.
DR AlphaFoldDB; A0A195C3C5; -.
DR STRING; 456900.A0A195C3C5; -.
DR GeneID; 108781101; -.
DR OrthoDB; 3837860at2759; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 6.10.280.150; -; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR11202:SF36; NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00461; WH1; 1.
DR SMART; SM00246; WH2; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
DR PROSITE; PS51082; WH2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542}.
FT DOMAIN 26..136
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 212..225
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 421..438
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 451..468
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 169..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..403
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57864 MW; CF1584E9258AC207 CRC64;
MKSDNTDMQR GTILLKPEEN EHVFQLIGNR CQCLAAGVIQ LYLTEAPLHK DWVKKNTGII
TLIRDNPRRS FFLRLYCLQR KIMLWEHEIY NSMDYKAPMS YFHTFEAEDC MAAFNFASET
EAITLRNVLL GKLNAKRQRR QERKAKEMQG SNTLPWKNQS SISSFTVTSG SSSNLSNGAI
GVNRSASSSS MHKTKKKRNE QDLKRKLTKD DIGLPSNFRH VAHLGWDVNN KGLELDSVDS
QLQQFFNNAG VSEYELQDKG TRKFIYDFIE RNGGMSAVQE DIRPLVNAKN SNQPPALPER
QEYPPPIPAR TIPHQIRTAP PLPPNRFNVS SALSNAPSNL PSSTPLNTLS NIPPIHRTLP
SRPPPPTIAS APALPPPPPP PPAPSKNSTN VPIPPPLPPL PDPTINTNVT NNNNEESITD
LRPMLMESIR SGTTLKKVDK TEMKPALVED SRCELLRQIR EGIELKPVRN EAKSNSVPAL
RGGLADALSR ALAERSRAIH SESEESTSDT TDDDEWDD
//
