ID A0A195C5G4_9HYME Unreviewed; 390 AA.
AC A0A195C5G4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Histone-lysine N-trimethyltransferase SMYD5 {ECO:0000256|ARBA:ARBA00026238};
DE EC=2.1.1.372 {ECO:0000256|ARBA:ARBA00024057};
DE AltName: Full=SET and MYND domain-containing protein 5 {ECO:0000256|ARBA:ARBA00033038};
DE AltName: Full=[histone H4]-lysine20 N-trimethyltransferase SMYD5 {ECO:0000256|ARBA:ARBA00029994};
GN ORFNames=ALC62_13143 {ECO:0000313|EMBL:KYM96092.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYM96092.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYM96092.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYM96092.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM96092.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, Rhea:RHEA-
CC COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.372;
CC Evidence={ECO:0000256|ARBA:ARBA00023940};
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DR EMBL; KQ978231; KYM96092.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195C5G4; -.
DR STRING; 456900.A0A195C5G4; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0042799; F:histone H4K20 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10521; SET_SMYD5; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044422; SMYD5_SET.
DR PANTHER; PTHR46402:SF2; HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5; 1.
DR PANTHER; PTHR46402; SET AND MYND DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..342
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 390 AA; 44457 MW; 8CF24FEDC5BCF932 CRC64;
MINDEVMADK GFFIKLVNDE KGKGLFSNRA FKEGDVILEE KPIICCQFLW NSQFGYLACD
HCLRPLETAE ENVRRLTGNP NFVVPHKECC EINKSLITEC HLCGVKYCSI ECQNEAFQRY
HSTLCLQGRV KDESHPLNQL CETWKQMHYP PESASIMLPA RMVAVVNQAN DKEEVLAMFS
QFCHRTVSND THEIVHYLLG EKFVGQIDIL QQMMKEALNT EYTSHWFTPD GFRSLLALVG
TNGQGIGTSS FSRWVKNVSA LELPKDERIY IDKLIEKIYD AMDEAVGPFL NNEGSGLYFL
QSSVNHSCVP NAIVEFPYSN NTLVLKAIRD IKNGEEICTS YLDECQLERS RHSRQQALSS
LYLFVCHCDK CQVQANDPDV TSDEEESDED
//
