ID A0A195CEG6_9HYME Unreviewed; 2108 AA.
AC A0A195CEG6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181};
DE AltName: Full=DRB sensitivity-inducing factor large subunit {ECO:0000256|ARBA:ARBA00029645};
DE AltName: Full=Transcription elongation factor spt5 {ECO:0000256|ARBA:ARBA00021370};
GN ORFNames=ALC62_10214 {ECO:0000313|EMBL:KYM99100.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYM99100.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYM99100.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYM99100.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM99100.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
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DR EMBL; KQ977876; KYM99100.1; -; Genomic_DNA.
DR STRING; 456900.A0A195CEG6; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 2.
DR CDD; cd06082; KOW_Spt5_2; 2.
DR CDD; cd06083; KOW_Spt5_3; 2.
DR CDD; cd06084; KOW_Spt5_4; 2.
DR CDD; cd06085; KOW_Spt5_5; 2.
DR CDD; cd06086; KOW_Spt5_6; 2.
DR CDD; cd09888; NGN_Euk; 2.
DR Gene3D; 2.30.30.30; -; 6.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 2.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 2.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 2.
DR Pfam; PF11942; Spt5_N; 2.
DR SMART; SM01104; CTD; 2.
DR SMART; SM00739; KOW; 12.
DR SMART; SM00738; NGN; 2.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Elongation factor {ECO:0000313|EMBL:KYM99100.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:KYM99100.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 146..237
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 242..269
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 396..423
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 448..476
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 571..598
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 679..706
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 743..890
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 957..984
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1220..1311
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 1316..1343
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1473..1500
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1525..1552
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1647..1674
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1755..1782
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1826..1949
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 2053..2080
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1362..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1451..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1105
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1839..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1917..1980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2108 AA; 234415 MW; AA2C8F6921989A03 CRC64;
MIPAEDSDNI SENKEEREVE QEEEDDDEDE EEDDDKRRKK KKKSRIASFI IDEAEVDDDV
EDDDEWEEGA QEFGIIENEV DELGPTAREI ERRRRNINLW DSDEDEIEEY LREKYSKSTA
GYRFGDGDKK MSEEIIQQTL LPGVKDPNLW MVKCRIGEEK ATALLLMRKF ITYQNSNEPL
QIKSVVASEG VKGYIYIEAY KQSHVKAAIK NIGSLRFGTW KQQMVPIKEM TDVLRIVKEH
TYLKPKQWVR LKRGIYKDDL AQIDYIDLAQ NHVHLKLLPR IDYNKFRGAL RTVQNESNVS
KCKKSRQPAK PFNPEAIRAV GGEVAKNGDF HIFEGNKYNH KGFLYKDFSI NNICAEGIKP
TLSELEKFEE ALQDIEIDSN ETPEFGTSGK KDQFYSFSTG DKVEVCKGEL INLRGKIISL
DGNTIMVMPK HEELKEVLEF QASELRKYFV QGDHVKVNIA RRYEGDTGII VRAEQNRIVL
FSDLSMHELE VFPRDLQLCS DVATGVDSLG KFQWGDLVQL DAQTVGVIVR LERENFHVLS
IHGKVVEARP QGLTKLRESR NAIALDSQQN IIQNKDIVKV IDGMHAGRGG EIKHLYRSFA
FLHSRIFIDN GGIFVCKTRH LQLSGGNKTI STNSMSPLLV GFMSPKMTSP MHPSGGSFER
SSEDRRGKGS GVGGVRRDRE LIGVIVKITS GPYKGNVGFV KDATQTTARV ELHSTCHTIS
VDRSHIASVG VLTRDGSFSS YNRTPNEIGG QTPTYENGSR TPHYGSLTPS QDGSRTPGQS
GIWDPTIGNT PARMNEFDEY NIEENSLLNY PLKYPSTEEP FIPQTPNIIY GSEQSFDSCS
SSTMENSSTV YSNPENYVAT PSTTNTGYVN NTLTMLNNYT PNSPYNPLTP HSEMDADNDS
DWHTTDIEVR IRDTHNDSAL VGQQGVIQQI SGNMCSVYLP TEDRVVSIVC KQLEPVKPSS
GDRVKVIQGE DREVVGTLLS IDNQEGVVKL INTDEIKFFQ FRLLAMQEAS EEDLGAFLAA
GVFREARDPG VRLYLDHVLA HHLDIILLYY NKVYFTHSSE DGDAKIDEAE EVRSGDEEIV
EMEEEPEGED LDDSSEYDEE EEEEDDDRPR KKKKKDRFGG FIIDEAEVDD EVEDDDEWEE
GAQEIGIVGN EVDELGPTAR EIEGRRRGTN LWDSQKEDEI EEYLRKKYAD ESIAARRFGD
GGEEMSDEIT QQTLLPGVKD PNLWMVKCRI GEEKATVLLL MRKFITYQFS NEPLQIKSVV
APEGVKGYIY IEAYKQPHVK AAIENVGNLR MGVWKQQMVP IKEMTDVLRV VKEQTGLKAK
QWVRLKRGIY KDDIAQVDYV DLAQNQVHLK LLPRIDYTRP RGALRTAQSE SEALKRKKKR
RPPAKPFDPE AIRAIGGEVT SDGDFLIFEG NRYSRKGFLY KNFTTSAIIA EGIKPTLSEL
ERFEEAPEGV EIDLSGTPGT GTSGKEDQSV AHSFSNGDNV EVCEGELINL QGKIVSIDGN
MIMVMPKHEE LKEALEFQAS ELRKYFTQGD HVKVVAGRYE GDTGLIVRVE QNRVVLFSDL
SMHELEVLPR DLQLCSDMAT GVDSLGQFQW GDLVQLDAQT VGVIVRLERE NFHVLSMHGK
VVEARPQGLT KRRENRNAVA LDSQQNTIQK KDIVKVVDGP HAGRGGEIKH LYRSFAFLHS
RMFVDNGGIF VCKTRHLQLS GGNKTTSINS MSPVAGFMSP RIASPMHPSG GSFGRGGGGG
RGRGRGGGSG ARRDRELIGT TIKITGGPYK GNVGIVKDAT ETTARVELHS TCQTISVDRS
HIANVGVPSK DGGFSSYNRT PAYGAGGQTP MYARDGSKTP MHGSQTPMYE NGSRTPHYGS
MTPSHDGSRT PGQSGAWDPT VTNTPARTND FDGYSIEEGG SPGYGPGYPP TGGPFTPQTP
GTMYGSEQSF SSYQPSPSPA GSATASPSPA GYVATPSPSG TGYTTSPHGI PGSPYNPQTP
GSGIDAGVGS GIIGSSEWHT TDIEVRIRDS HDDPALAGQQ AVIRGISGGM CTVYLPTEDR
VVNLVCEQLE PVVPSRGDRV KVILGEDREA VGTLLSIDNQ EGVVKLNTDE IKFLQLRFLC
KMKDTKQG
//
