ID A0A195DV50_9HYME Unreviewed; 1015 AA.
AC A0A195DV50;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE SubName: Full=Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter {ECO:0000313|EMBL:KYN16434.1};
GN ORFNames=ALC57_11304 {ECO:0000313|EMBL:KYN16434.1};
OS Trachymyrmex cornetzi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=471704 {ECO:0000313|EMBL:KYN16434.1, ECO:0000313|Proteomes:UP000078492};
RN [1] {ECO:0000313|EMBL:KYN16434.1, ECO:0000313|Proteomes:UP000078492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tcor2-1 {ECO:0000313|EMBL:KYN16434.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN16434.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex cornetzi WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KQ980341; KYN16434.1; -; Genomic_DNA.
DR RefSeq; XP_018367834.1; XM_018512332.1.
DR AlphaFoldDB; A0A195DV50; -.
DR STRING; 471704.A0A195DV50; -.
DR GeneID; 108764209; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000078492; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF48; GH09711P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078492};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 90..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..585
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 594..1015
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 112356 MW; 05E1FC39D0936EAD CRC64;
MENRFQSKTQ EDDVIGQLPS NKRPSMSLSM GGLWDVVPRL DHYRLSRRAK RPSLSTLHEG
NLIKDANSVE TGQVGSVVGQ QGHVGIKLGW IQGVLIPCLL NIWGVMLFLR LSWIVAQAGI
LQTIVIIGIS AVVCVITTLS LSAISTNGEV KGGGIYFIIS RSLGPEFGAS VGIVFAFANA
VAASMNTIGF CDSLNDLLKT NDLKIIDNSV NDVRIVGIIA LIVMILVCAI GMEWESKAQN
FLIAIIVSAI FDFLIGTIMG PQNEEQKAKG FIGFSADVFM ANLGSNYRYS EKNNQTFFSV
FSIFFPSVTG IQAGANISGD LKDPASSIPI GTLLALLISM FSYATFVFFA GAAAARDAGG
FVNSTVVDCI PGFNCTYGLH NSYSVMQLMS LWGPLIYAGC FAATLSTALT NLLSVPRLIQ
ALGQDRIYPG LIYFSKRYGK SGEPYRGYVL TFVVAALFLL IADLNAVAPL ISNFYLASYA
LINFCTFHAA LIRPLGWRPS FKYYNTWLSL MGFILCVAIM FLIDWVTSLV TFVIIFALYL
IVVYRKPDVN WGSSTQAQTF KTAISIVYRL NSIDEHVKNY APKILALTGP PAARPALIHL
ANLITKNNSL LIAGEVFPTR LSYRLRSVRL NNGSFWLQQQ RIKSFYHLVD DLSLERGAAA
LMQATGIGKL APNVVLMGYK THWSMCNHKD LQEYFNILHN AFDNKLAVAI LRIAEGLDCS
GITNGEDTNG EDDHGGLVQS SYNLAGNTLM HADSNLSMST QIPRVQSVPT IGTSFVTPDT
TPVIGYSTIN WKAHDNMKQK RKHAVDKLFE RRNGGMASIP ENVTIFQQKY KKGTIDVWWL
YDDGGLTVLL PYIISTRSNW KHCKMRIFAL TNHKHDISAQ EKEMIEIMNK ARINYSSLKI
VDDIGVELKE ETRIFFDKLI SDFRINDSSS VNGECYITEN ELQTLREKTH RQLRLRELLL
ENSSKSTLVV MSLPMPRKGA VSAPLYMAWL ETLTKDMPPT ILVRGNHTSV LTFYS
//
