ID A0A195EDT2_9HYME Unreviewed; 1398 AA.
AC A0A195EDT2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN ORFNames=ALC57_04139 {ECO:0000313|EMBL:KYN23266.1};
OS Trachymyrmex cornetzi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=471704 {ECO:0000313|EMBL:KYN23266.1, ECO:0000313|Proteomes:UP000078492};
RN [1] {ECO:0000313|EMBL:KYN23266.1, ECO:0000313|Proteomes:UP000078492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tcor2-1 {ECO:0000313|EMBL:KYN23266.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN23266.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex cornetzi WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KQ979039; KYN23266.1; -; Genomic_DNA.
DR STRING; 471704.A0A195EDT2; -.
DR Proteomes; UP000078492; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06373; PBP1_NPR-like; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF494; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KYN23266.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078492};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1398
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008270775"
FT TRANSMEM 511..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 670..944
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1020..1150
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1229..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1398 AA; 156355 MW; E4CBAA68484E6E23 CRC64;
MASRTRKRWC GNGGVLVRLT LTLSGLCAGQ CTNIGLMTMT TTTMTRTSTT ETGTTMTMTA
GGSRECIGGV RTMSEGEVKL AVIAPGDPHH EQSLQRVLPA VLLAVKYVSS PRGPLPGWNI
KVDYRDSYCS STYGPLAAFE FYINQTADAF LGPVCDYVIA PVARYAGVWG IPVLTAGAQA
EAFRHKGQHY PTLTRMMGSH RLVGEALRHI LRSFGWKICG LLFHNHEMAS SKGNSECHFT
LSAVYTALNQ TPAHKSFNQE TADTDEYKNL LSFIAKSARI IVMCANSTTI REILLAAEEL
GMVDSGEYVF FSIELSSSDN DSKEPWRVDG DTDERNKKAR KAYQALLTVT ARTPDNLEYL
NFSREVKSLA QSKYNFIFGN SSVSTFVTAF YDAVLLYALA LKESLPEKPG EVNLDGGNLT
RQMWGKSFKG ITGDVNIDEN GDRIADYSLL DMDPKTSRFE IVANYYGANK TLEYIPGKQI
HWAGGRLEPP PDTPTCGFDG SLCPDNSLPG YAILSMVLSS IVVVLVVGSV FIYRRFKLEA
EIVSMTWKVH WDDVIVIPNA KTRGSMYSLI ANKFRGSELV RYSVDAFLII SLHSVKKQKR
KRPFLNLFVL FSYTTNKRKN RKKISFFPYS LNFTFIYKAC RSFLFNDRIF DQFSLSRFNL
IEMSSQQYFF PHVKQLSAKN IFQMKEITLS FNNSIDNSKV AIKLIPRNKV EISRPLLLEL
KRMKDLQHDH LVRFYGACLE PPHCCLLTEY CPKGSLQDIL ENEQIKLDRV FRGSLTHDIV
RGMAYLHASE VKSHGNLKSS NCVVDSRFVL KIADFGLHEL RRNADVDSDG DKNSYAYWRK
QLWTAPELLR MERQLPEGTQ KGDVYSFAII VHEIVMRQGP FYLGDNNELS PKEIIEGVRR
GGGSPLRPII DDASVEEEVA TLMRRCWAQE AADRPDFPAL KQTIRKINKD YESSNILDNL
LSRMEQYATN LETLVEERTA DYLEEKRKCE ELLYQLLPKS VASQLILGQS VIAETYDQVT
IYFSDIVGFT SLSAESTPLQ VVDLLNDLYT CFDSIIENFD VYKVETIGDA YMVVSGLPVR
NGMNHAREIA RMSLALRDTV MTFSIRHRPT EQLKLRIGMH SGPCVAGVVG LKMPRYCLFG
DTVNTASRME SNGEALKIHV SPKTKEILDT FGTFELVCRG EVILKGKGPM TTYWLMGEIP
TNNNVQQANP TTTVSQISIL QDQPPITTQI QTTQTKQQEQ RALSSVNQQH KFQGQSEQPY
PTQQSIQSRS QEPRQQGHPG QQRPQELQHQ GLMTVQSRCQ AVQTNPSSTT NQIQGQRSAT
VNPACVTGNG APKSVIASRT VVATPIGNSS PSRNRTSGPP SANNSMHQVY PTAENMPNHT
ESGPNAPLLL PAGAIPRV
//
