ID A0A195EYJ1_9HYME Unreviewed; 1505 AA.
AC A0A195EYJ1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Activated CDC42 kinase 1 {ECO:0000313|EMBL:KYN33360.1};
GN ORFNames=ALC56_12071 {ECO:0000313|EMBL:KYN33360.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN33360.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN33360.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN33360.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN33360.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KQ981905; KYN33360.1; -; Genomic_DNA.
DR RefSeq; XP_018350895.1; XM_018495393.1.
DR STRING; 34720.A0A195EYJ1; -.
DR GeneID; 108753625; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05040; PTKc_Ack_like; 1.
DR CDD; cd09539; SAM_TNK-like; 1.
DR Gene3D; 4.10.680.10; Cdc42-like binding domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015116; Cdc42-bd-like.
DR InterPro; IPR037085; Cdc42-bd-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR032065; RNF31-UBA.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR049587; TNK-like_SAM.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24418:SF294; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF09027; GTPase_binding; 1.
DR Pfam; PF16678; HOIP-UBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SMART; SM00165; UBA; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KYN33360.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000078541};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 110..376
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 372..432
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1461..1503
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 727..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..780
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 142
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1505 AA; 167900 MW; 6321F8DBE8C245E3 CRC64;
MADEEGIKWL QELLHDVQLS QFFTRIRDDL QITRLHHFDY VQAEDLEKIG LGKPGVRRLL
DAIKKRRNAQ WKKSLITKIK PGSSGKSNKR ASQSVETSSV LTCLIQDKDV TLSIKLGDGS
FGVVRRGEWI SPSGRTLPVA VKVLKEDALT QPNVIEDFIS EVQAMHTLDH HNLIRLYGVV
LSQPMMMVTE LAPLGALLDY LRQQCSRISI LTLCNYALQV ATGMAYLETK RFLHRDLACR
NVLLSTIDKI KIGDFGLMRA LPQQEDCYVM TEHKKVPFPW CAPESLKARH FSHASDVWMF
AVTLWEMLTF GEEPWIGLNG SEILRKIDRE GERLHKPEAM PPYMYELMLR CWAREPSERP
TFASLKESLT GMVPSVMKAL TSFEETDKMS IESGDQIAII DGRPENYWWK GQNQRTFQIA
HFPRCLVDPM RRKQPEDISK PLENSFIHTG HGAPFGKSWG SPVYIDDVYL RNPMDPPDVL
VASSVDNQTK KKFSCGTPRT KKQFNYTKLH NDARSSPIKS SQVSSTSSVS QEDTLIDLSV
EESANTNMHV ACKRVINILD EPIDDERLSW QDEEGRTYAN FPGNVDPAYS DPFDTSAVFM
KPPHSRYYSH VPTDVANNYL KTQTYGNVND QKERENVQDT VNNSTDTEET CQYSMNLYKG
CQENAINLNT DVKEDDITNH YSEIDKISPC ASSWSTWSNW PEDLRKTSAA QTYVNISDNS
SVSSFAATIP PHPLPLLPPS PPPPPPPPPP PPPSLPSLPS LSSLPSLPSL PPPPPLSHVN
LPKPKSNFEL AQSMNELSLN TNSDRQEVTA VAKKLDPVFL AELEKHLGEK EATKNTNASN
SKRQQPETVS ANSSLEKLQQ NSTSTHQISM MEDAARPLSL IPALKPPPQG KPKSPVATIN
RANTLSTSSN KVQNFWQPKS TNVERPRLQN DHCVSESATE VIMNQIWQQT QGLSQQTSPN
ICLTNSAANQ ILMSVSVTQA NVNRLQETAT NAFDNDTNDQ NQYSSYNVTK ATLIQTQACL
SDQTYPQNTL HANQDNINLF EGTSDHTTDS NTNEAQHGSC NLAKTAVDQT QICSSNSQSY
LPNSLSIDHD VFNLQQIAIS NISSSARNYL QCDAANISKV NQTQICSLTN GSQHYLQNTD
FNLLQTTANY VSDKSTGEFS QHGHCNISKV ASNRAQIYSL SNQNYSPSVA PGFCMGDFAL
PQTCPQNMAV SSSTSNVHEI AHIQNNLQQS QQLKPVTLLS QQVYAELKQT VPNLEQLSQN
EFNTLYNKTV RQNILRNYYS NNLSNESSQN HVQESAGNQP LQKSINLKNQ PIQGHACDFS
SYLKQPPTYT PPPAPLTTRS LLKSSQNDYM QSHNPAIKCN LSRPSNLLQA EASTSTKSAL
TTLNDFAAAK VNLLQVNQHS ACTSPPLTAA SQQLVMSLSD EFRMSKIMKV QKETVDASQQ
EILAALQATG WDTNQAAKQI TKDRQVKLEN LMRLGLATKQ QCENALKQTK YDVEEAASLL
LDQAR
//
