ID A0A195F695_9HYME Unreviewed; 368 AA.
AC A0A195F695;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Glyoxylate reductase/hydroxypyruvate reductase {ECO:0000313|EMBL:KYN35906.1};
GN ORFNames=ALC56_09697 {ECO:0000313|EMBL:KYN35906.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN35906.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN35906.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN35906.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN35906.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; KQ981768; KYN35906.1; -; Genomic_DNA.
DR RefSeq; XP_018347142.1; XM_018491640.1.
DR AlphaFoldDB; A0A195F695; -.
DR STRING; 34720.A0A195F695; -.
DR GeneID; 108751435; -.
DR OrthoDB; 6392at2759; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF257; GLYCERATE DEHYDROGENASE HPR, PEROXISOMAL; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}; Pyruvate {ECO:0000313|EMBL:KYN35906.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078541}.
FT DOMAIN 55..360
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 154..332
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 368 AA; 40861 MW; 54E6644785D6FD3E CRC64;
MVFANVVRLI RQSERILHTK RIGWTICDYP RVLISNDSNT VEMSKPKILI TRPDIPVAGL
NLLRKRYHLI IWDRPEPIPR AELLAKIYGV DAVFCMLTDK IDNEILDHAG SQLKVVASMS
VGLDHLDISS LQRRNIKIGY TPNVLTESTA ELIIALLLAI SRNVVHANLA VYKGEWTSWS
PVWMCGTGLR GKIVGIVGLG RIGSRVAEIL KSFNVSKILY FNRTVKEEAS KFDGEKVDFP
TLLQNSDFVI VTVALTPQTR YMFNSWAFNQ MKKTAIFVNG SRGDVVDQQA LIDALKNNTI
AAAGVDVTTP EPLPIDHELL ALDNCVVLPH IGSATIETRN EMACITAKNI IAVLEGEEMP
AEYGKINS
//
