ID A0A195F9J6_9HYME Unreviewed; 2068 AA.
AC A0A195F9J6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=ALC56_08842 {ECO:0000313|EMBL:KYN37051.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN37051.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN37051.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN37051.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN37051.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KQ981727; KYN37051.1; -; Genomic_DNA.
DR STRING; 34720.A0A195F9J6; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 5.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:KYN37051.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078541};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 133..160
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 782..805
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 826..843
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 855..879
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 899..928
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 990..1011
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1271..1289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1309..1328
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1335..1358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1389..1407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1428..1457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1546..1570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1633..1651
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1663..1682
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1694..1713
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1757..1780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1847..1870
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1887..1922
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 35..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 419..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1213
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2068 AA; 235309 MW; 96BBB2C1BFE22E61 CRC64;
MSEDSDSISE EERSLFRPFT RESLAAIGAR IAEEEARQKE LQQRRAEGEV RYDDEDEDEG
PQPDPMFEQG APIPVRLHNE FPPELASTPL EDIDSFYHNQ RTFVVISKGK DIFRFSATDA
MWMLDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTIESTE VIFTGIYTFE
SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KNFPEDGSWG
NLTHESWARF NNNETNWYFD EAKNIPLCGN SSGAGQCLPG YTCLQGFGSN PNYGYTSFDT
FGWALLSAFR LMTQDYWENL YQLVLRSAGP WHMLFFIVII FLGSFYLVNL ILAIVAMSYD
ELQKKAEEEE AAEEEAMREA QEAAIAKENK LAAREAAAAA AAAAADAAAE AADQIVKSPS
DFSCHSYELF VGQEKGNDDN NKEKMSIRSI ESIGDQRHIK QINNNHSAAN KVRKVSAASL
SLPGSPFNLR RSSRGSHQFT IRNGRGRCFV PPGGDRKPLV LSTYLDAQEH LPYADDSNAV
TPMSEENGTI VVPVYYANLG SRHSSYTSHA SRLSYTSHGD LAFSGIRGID SIGKQITKQE
QILRNRNNKQ TPANGHVTDA NQKNYHFEAP DMEDPMGKNK PQDNPFIELP AQQHTVVDMK
DVMVLNDIIE QAAGRRSKTP EQADDDEEPT FKDKLVAGMF RCIDIFCVWD CCWLWLEFQK
YVSLLVFDPF VELFITLCIV VNTLFMALDH HDMDKDMERV LKSGNYFFTA TFGIEATMKL
IAMSPKYYFQ EGWNIFDFII VALSLVELGL EGVQGLSVLR SFRLLRVFKL AKSWPTLNLL
ISIMGRTVGA LGNLTFVLCI IIFIFAVMGM QLFGKNYVDH VDYFPDGDLP RWNFTDFMHS
FMIVFRVLCG EWIESMWDCM LVGDVSCIPF FLATVVIGNL VVLNLFLALL LSNFGSSNLS
APTADNDTNK IAEAIDRIAR FIKWIKRNIL AFAKLMRAKL TNQISDQAPD GIDRDGDLDL
ADGELDVYRD KKSAKELNQL EVAIGDGMEF TIHGDLKNKL KRGKLCMNNT KVIANSINHH
DYRLDNDYIN QNEDDTISNK SYGSHKNRAF KDESHKGSMD SLNGEEKKDA SKEDLEQEED
LEDEGEEEED RLDVEIIQVD EDPIQSIYPA DCCPENCYKK FPFLAGDDDA PFWQGWANLR
FKTFRLIENK YFETAVITMI LLSSLALALE DVHLQQRPVL QDVLYYMDRI FTVIFFLEML
IKWLALGFKK YFTNAWCWLD FIIVMLSLIN LGAVWAGAAD IPAFRSMRTL RALRPLRAVS
RWEGMRVSLI NFVASLCGAG GIQAFKTMRT LRALRPLRAM SRMQGMRVVV NALVQAIPSI
FNVLLVCLIF WLIFAIMGVQ LFAGKYYKCV DTNKTTLSHE IIPDRNACNT ENYTWENSPM
NFDHVGKAYL CLFQVATFKG WIQIMNDAID SREIDKQPIR ETNIYMYLYF VFFIIFGSFF
TLNLFIGVII DNFNEQKKKA GGSLEMFMTE DQKKYYNAMK KMGNKKPLKA IPRPRWRPQA
IVFEIVTDKK FDMIIMLFIG LNMLTMTMDH YQQSVTFGNV LDYLNMIFIV IFTSECLMKI
FALRYHYFKE PWNLFDFVVV ILSILGLVLS DIIEKYFVSP TLLRVVRVAK VGRVLRLVKG
AKGIRTLLFA LAMSLPALFN ICLLLFLVMF IFAIFGMSFF MHVKDKSGLD DVYNFKTFGQ
SMILLFQMST SAGWDSVLDG IINEEDCQEP NNEIGYPGNC GSSTIGIAYL LSYLVISFLI
VINMYIAVIL ENYSQATEDV QEGLTDDDYD MYYEIWQQFD PDGTQYIRYD QLSDFLDVLE
PPLQIHKPNK YKIVSMDIPI CKGDLMFCVD ILDALTKDFF ARKGNPIEET GDLAEVQARP
DEAGYEPVSS TLWRQREEYC ARLIQNAWRK HKQQRLGGPS EESDDPDTDL CVRQTKVLVE
SDGYVTKNGH RVVIHSRSPS VTSRTADV
//
