ID A0A195FJN4_9HYME Unreviewed; 735 AA.
AC A0A195FJN4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=ADAM 17-like protease {ECO:0000313|EMBL:KYN40576.1};
GN ORFNames=ALC56_04885 {ECO:0000313|EMBL:KYN40576.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN40576.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN40576.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN40576.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN40576.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; KQ981522; KYN40576.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195FJN4; -.
DR STRING; 34720.A0A195FJN4; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd14246; ADAM17_MPD; 1.
DR CDD; cd04270; ZnMc_TACE_like; 1.
DR Gene3D; 4.10.70.30; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR034025; ADAM10_ADAM17.
DR InterPro; IPR032029; ADAM17_MPD.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR PANTHER; PTHR45702:SF6; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17; 1.
DR Pfam; PF16698; ADAM17_MPD; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13574; Reprolysin_2; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KYN40576.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Protease {ECO:0000313|EMBL:KYN40576.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078541};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 226..470
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 471..562
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT REGION 195..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 402
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 406
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 412
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 735 AA; 84228 MW; E58080A6E94B6BA7 CRC64;
MKTLLIGGLH RSLKYYETIH STHFQHRVLK RGIQHSYHPY NRISELEFYS HGRHFRLILT
PRREVIHSNF KAYEVNADGK EKTVHLDHDN FYHGRVFGEI ESHAQMHIDD GIMTGSITIL
DETFHIEPSQ IIAYNNSLIK PSWRHLSHLD NQTMIIYKSS DVKLSWEHYQ DGEGHTHGTP
KTCGYVKEDI NYTLNDNSEE DDTEMDNSSS RVKRQTETYE YTPTKTRCPL LLVADYRFYQ
EMGASSTKTT INYLISLIDR VHKIYNDTLW QEHQEEDGFK GMGFVIKKIV VHSEPTRVRG
GETHYNMVRE KWDVRTLLEV FSREYSHKDF CLAHLFTDLK FEGGILGLAY VGSPRRNSVG
GICTPEYFKN GYTLYLNSGL SSSRNHYGQR VITREADLVT AHEFGHNWGS EHDPDISECS
PSASQGGSYL MYTYSVSGYD VNNKRFSPCS LRSIRKVLQA KSGRCFSEPE ESFCGNLRVE
GDEECDAGLL GTEDNDSCCD KNCKLRSNQG AVCSDKNSPC CQGCAYMPAG VKCRDAQYAT
CEQESRCTGA SSECPRSPPM KDGTDCLERG QCRLGKCVPY CETQNLQSCM CDTILDACKR
CCRMNLNETC FPIDQQDILP DGTPCIQGFC NKGVCEKTIQ DVVERFWDII EDININKVMR
FLKDNIVGAV IIITAVIWIP ASCVISYIDH RRVKESEKKW QWKHTDELIH PEEPRQVIYV
GGQRQQRVQH VMHQS
//