ID A0A195FQ00_9HYME Unreviewed; 1078 AA.
AC A0A195FQ00;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 29.
DE SubName: Full=Tyrosine 3-monooxygenase {ECO:0000313|EMBL:KYN42543.1};
DE Flags: Fragment;
GN ORFNames=ALC56_03089 {ECO:0000313|EMBL:KYN42543.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN42543.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN42543.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN42543.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN42543.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; KQ981340; KYN42543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195FQ00; -.
DR STRING; 34720.A0A195FQ00; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR GO; GO:0042423; P:catecholamine biosynthetic process; IEA:InterPro.
DR CDD; cd03345; eu_TyrOH; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR041903; Eu_TyrOH_cat.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR005962; Tyr_3_mOase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF15; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KYN42543.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000078541}.
FT DOMAIN 225..571
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT REGION 100..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 546..573
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 404
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 409
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 449
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KYN42543.1"
SQ SEQUENCE 1078 AA; 122971 MW; 9F17A49019D1659D CRC64;
NGYPARRRSL VDDARFETLV VKQTKQSVLE EARQRANVCN ICICMLMLMH DVFLCYRIDT
NADQTITCTK KKGQEDNYID ISSSDDEQVE SLVCAVQEEE AKAEASSDSD GKPDDDDDDD
DVRFFTDAGL TEEEVVLAKT IAESPDSEQN VQKAALVLRL REGIGSLGRI LKTIENFKGT
ITHVESRPSK KEGLQFEVLV KIDMSRQSLL QLIRNLRQSS ALDGVNLLAD NSVSIKDPWF
PRHASDLDNC NHLMTKYEPD LDMNHPGFAD KEYRARRKVI AEIAFAYKYG DPIPSIPYTE
TENETWSRVF NTVLDLVPKH ACMEYQRVFK KLQEERIFES HRIPQLQEVS DFLKKSTGFT
LRPAAGLLTA RDFLSSLAFR IFQSTQYVRH INSPYHTPEP DCIHELLGHM PLLADPSFAQ
FSQEIGLASL GASDEEIEKL STIYWFTVEF GLCKEGPEVK AYGAGLLSAY GELLHALSDK
CEHRAFDPSI TALQKYQDQE YQPIYYVAES FEDAKEKFRR WVATMSRPFE VRFNPHTQRV
EVLDSVDRLE GMISQLNTEM THLTNAVNKM KARQFAACCI LIDTVANGLK FALDTDEVKH
EKIKTRYENE SKVLRIQELY RKVYEEDTRN SQKYINKTNL DNNNHKSIRK HKSKKFRAKH
TIGGKHERHR HNRHHQNAIN NMLPESNAMI TANKSQQITI IDEKCKKDNV IVLQDTILKT
TCTMSADKLQ NNIDSEQENS LNKKADSSTI SEIIDKNDTK KFKTSSQKQE NISNIDTNTK
MQTKQNFDGM KYEEVTVLSR RQSSKDCVTI INKQMDSRYE KLFTKRHDGL GKKTHRFSHD
IKSFTHDCYE NSLITNMTNA CSMTSNAIRG IRRKKSSLCE VKVAVIGAPG VGKSALTVRF
LTRRYIGEYD HQSETRYKHE VLVDGEPILF EILDTCPKSE DELPSMETLQ WADGLLLVYS
ITDRNSFNFV RKAKEALAVA DPEAAMPLAL VGNKADMVHL RQVSAEEGEI LAKDFECWFS
EITAAEQVAQ VAESFHELCR EVLAARRRNK QSLLDRMLGG KATRAYSRGK SDSALPKD
//
