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Database: UniProt
Entry: A0A196S472_BLAHN
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ID   A0A196S472_BLAHN        Unreviewed;       914 AA.
AC   A0A196S472;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   22-FEB-2023, entry version 26.
DE   RecName: Full=AP-2 complex subunit alpha {ECO:0000256|PIRNR:PIRNR037091};
GN   ORFNames=AV274_6389 {ECO:0000313|EMBL:OAO11938.1};
OS   Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO11938.1, ECO:0000313|Proteomes:UP000078348};
RN   [1] {ECO:0000313|EMBL:OAO11938.1, ECO:0000313|Proteomes:UP000078348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA   Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA   Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA   Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J., Ball S.G.,
RA   Clark G., Dacks J., Van Der Giezen M., Tsaousis A., Roger A.;
RT   "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC       clathrin to receptors in coated vesicles. Clathrin-associated protein
CC       complexes are believed to interact with the cytoplasmic tails of
CC       membrane proteins, leading to their selection and concentration.
CC       {ECO:0000256|PIRNR:PIRNR037091}.
CC   -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC       {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004277}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR037091}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAO11938.1}.
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DR   EMBL; LXWW01000573; OAO11938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A196S472; -.
DR   STRING; 478820.A0A196S472; -.
DR   OrthoDB; 25313at2759; -.
DR   Proteomes; UP000078348; Unassembled WGS sequence.
DR   GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.40.1230; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR   InterPro; IPR017104; AP2_complex_asu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR003164; Clathrin_a-adaptin_app_sub_C.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR   PANTHER; PTHR22780:SF4; AP-2 COMPLEX SUBUNIT ALPHA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02296; Alpha_adaptin_C; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   PIRSF; PIRSF037091; AP2_complex_alpha; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR   SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE   3: Inferred from homology;
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR037091};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583, ECO:0000256|PIRNR:PIRNR037091};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037091};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR037091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078348};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037091}.
FT   DOMAIN          677..783
FT                   /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT                   Ig-like subdomain"
FT                   /evidence="ECO:0000259|SMART:SM00809"
FT   REGION          612..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..667
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   914 AA;  103672 MW;  5CB98A8FB69FB470 CRC64;
     MALRMRTLKN FINDIKNCQT KEAESTRVMQ ELATIRNSFT SAKLTAADRK KYVWTLVYIY
     LLGYEIDFGH MEVITLISSP NFQEKQVGYL AAAVLFKCTD KLFTLIVNSM RNDVINGVEV
     NQILALSAVA NLGGRDLAET LLEDILQLVQ KDTTTHLVKQ KCALTLLSLF RSSPDTVGTQ
     WIDKVLPMFD IRANIGCALS VSGLLANLIP HIKEEEMIDE IRHISIGVLR TLVLDKVCPE
     NYVYYDVPCP WLVVNCLRIL KSCPYPTSKK DVNLLEDALH TILQRNEMTK NRNHDNVTHG
     ELFEAVNLII SYGNETDPEL RASVVSYLGR FIMYEEPNIR YLGLDYMSRL AQLSGVSDKI
     KKHQDTIMAS LEDPDLAIRK RALHMLFSMC DEENAEEIVK KLLEHLKTPD FLIKEEMALK
     TAILAERFPP DNQWYIDVIT DLMLNAGDFV SDDIWHRMVQ IVSQQDDLQE YACHKMFELL
     QPTTVHEIMV RAGTYILGEY AELIVEPEIE GNEPVEPEAI LETLQRHYVK VSLNTQTLMM
     TAFAKLLVQF EELEDEIREL FEQNLSHIDS EMQQRAVEYN ALADSEIMED VLDQMPPFAE
     DRENVLEMKL KAPEEAEEEE EEEDDDDDDD DDDDDDDDDD DDDDDDDDDE EEEEEEEDGE
     AEGIDEETEE KLPAWFNKCV TKEKAVLFQD EHLQIGMTKD VQGATARFNL FYTNKSDSTL
     KKFSAEVESE ESGLAIEATE CNSTIEAGAK GKQQVTVTCN KPFAESPVLT VSFSCDGTTY
     KFPITFPVVG CTFCTPAELD ADTFQQRWSN PKLQEKEAKE TFRAAEDKGI ETLETVLPTL
     GFNIVEDVDE SANKVYAAGT FVTSKIAASG KPMTVSVLCL FEWAKAKRAY RLTVRASNET
     VATVCEEHLK AQLA
//
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