ID A0A196S753_BLAHN Unreviewed; 767 AA.
AC A0A196S753;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=CCR4-NOT transcription complex subunit 4 {ECO:0000313|EMBL:OAO12885.1};
GN ORFNames=AV274_5418 {ECO:0000313|EMBL:OAO12885.1};
OS Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO12885.1, ECO:0000313|Proteomes:UP000078348};
RN [1] {ECO:0000313|EMBL:OAO12885.1, ECO:0000313|Proteomes:UP000078348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J., Ball S.G.,
RA Clark G., Dacks J., Van Der Giezen M., Tsaousis A., Roger A.;
RT "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAO12885.1}.
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DR EMBL; LXWW01000501; OAO12885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A196S753; -.
DR STRING; 478820.A0A196S753; -.
DR OrthoDB; 295658at2759; -.
DR Proteomes; UP000078348; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR005069; Nucl-diP-sugar_transferase.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF03407; Nucleotid_trans; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000078348};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 18..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 133..216
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 70..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 87640 MW; 1528BE1C5265DCA3 CRC64;
MLNDTIDMNG DNEDDHLCPV CFGPMDETDY RLFPCPCGFQ LCMWCLHRLL NENSRCPNCR
ETYDRNRFKV VEEPDAREES DSSSEEANEE AEQPTGNSTA PGPRKRTNDV ALPVDAHSQH
NYQLSVTRIV QRNLAYIVGM PADENDVERL RSEEVFGKYG KVLKLVVSSP SVQSTQNPTI
GIYLTYENEE AALRCIRAVD GFCYKGHLLK ASFGTTKYCN SFIHNTTCLN QDCLYLHHKA
PAEDCFLRDE MTAGDSAFYK RTHPGFGSFW DSRRGVFVYH RRNALRSGDV LPENQGKAEE
ISNCLRKYSR VRFEVLGKNY EKTKKNVAAP PHDIKKGSIQ FRGSLEDSPL TSDVSEDEEP
EPEDPTSVDL NQLFSTPSKE PAANPTPSDS ISEEDILSNL IKADRTRKQT ESSYSPRNSH
FQDVNGEHVV SLRELVPERQ KDGVVMVTFT DMGYIDSFYL SNELSHLQSY SNLAVVAIEI
SAYIELKEKG FPVAFFNITS LAGRVGATPS LFGTNVFKQK MNAKQRIIRE VLLLNCSCLL
FDSDVILHKN PLPGILLRKH YDMLAQKDER VNSGFVFFRP TLTSIHFLNH VIRFMPVWGL
SDQPTTNRLI DENRVPAFRW GLLPEEEYSS GLVFFAKHQF RWDAINATQV TIHNNYILGE
WNKMYRLKEM GLYRFDKNRE YSDTKATFLY LQESRRGFEN RSLALGVELA NRLNRSFVVP
ILPCSNEVQL SKCNLCGNQF RFCHHDILQN ATLPWKEHVI SVNNPHQ
//
