ID A0A196SGT7_BLAHN Unreviewed; 279 AA.
AC A0A196SGT7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=cathepsin X {ECO:0000256|ARBA:ARBA00012516};
DE EC=3.4.18.1 {ECO:0000256|ARBA:ARBA00012516};
GN ORFNames=AV274_2018 {ECO:0000313|EMBL:OAO16238.1};
OS Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO16238.1, ECO:0000313|Proteomes:UP000078348};
RN [1] {ECO:0000313|EMBL:OAO16238.1, ECO:0000313|Proteomes:UP000078348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J., Ball S.G.,
RA Clark G., Dacks J., Van Der Giezen M., Tsaousis A., Roger A.;
RT "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of C-terminal amino acid residues with broad
CC specificity, but lacks action on C-terminal proline. Shows weak
CC endopeptidase activity.; EC=3.4.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001594};
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAO16238.1}.
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DR EMBL; LXWW01000092; OAO16238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A196SGT7; -.
DR STRING; 478820.A0A196SGT7; -.
DR OrthoDB; 5475703at2759; -.
DR Proteomes; UP000078348; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02698; Peptidase_C1A_CathepsinX; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033157; CTSZ.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF929; CATHEPSIN Z; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000078348};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..279
FT /note="cathepsin X"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012091112"
FT DOMAIN 43..274
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 279 AA; 31258 MW; 1F5F681BE1F6DAA7 CRC64;
MNSALALMLV ALVAARGCLD PNNKIPDVVK TPQPWQYMTN EELPKSYDPR NIDGVSYVSV
TKNQHIPQYC GSCWAQGSTS AIADRFNLMR KGAWPSVELS VQEVINCGHS GSCHGGWDSG
VYAYAEKEGI PDQTCQVYEA KDKECSDMNR CVDCDPDKGC FPIKEYKRYK INEYGSVSGA
EKMKAEIYAR GPISCFVEVT QQFLDYTGGL FVETDHAGLG GHIIEVTGWG KTEDGQEYWI
GRNSWGEYWG ENGWFRIQMY KDNLEIETGC TWGVPIIDF
//
